Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer

Guoping Ren; Xiaoyan Liu; Xueying Mao; Yanling Zhang; Elzbieta Stankiewicz; Lucy Hylands; Rongrong Song; Daniel M Berney; Jeremy Clark; Colin Cooper; Yong-Jie Lu

doi:10.1002/gcc.21984

Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer

Guoping Ren, Xiaoyan Liu, Xueying Mao, Yanling Zhang, Elzbieta Stankiewicz, Lucy Hylands, Rongrong Song, Daniel M Berney, Jeremy Clark, Colin Cooper, Yong-Jie Lu

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

We recently found that TMPRSS2:ERG fusion genes and PTEN loss, which are common in Western prostate cancers are infrequent in Chinese cases. As previous studies indicated a higher frequency of RAS and BRAF mutation rates in Eastern Asian than in Western prostate cancers and fusion genes involving the RAF family genes BRAF and RAF1 were recently identified in prostate cancer in the American population, we investigated BRAF and RAF1 alterations in Chinese prostate cancer. Using fluorescence in situ hybridization, we found that BRAF was truncated in five of 200 informative Chinese cases (2.5%) and that RAF1 was truncated in three of 204 informative cases (1.5%) and genomic rearrangements of these genes were significantly correlated with high Gleason scores (>7; P

Original language	English
Pages (from-to)	1014-23
Number of pages	10
Journal	Genes, Chromosomes & Cancer
Volume	51
Issue number	11
DOIs	https://doi.org/10.1002/gcc.21984
Publication status	Published - Nov 2012

Keywords

Aged
Base Sequence
China
DNA Mutational Analysis
Gene Dosage
Gene Rearrangement
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Male
Middle Aged
Molecular Sequence Data
Oncogene Proteins, Fusion
Prostatic Neoplasms
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf

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10.1002/gcc.21984

Cite this

@article{f7d6ee53317447aa96bb6422b6888164,

title = "Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer",

abstract = "We recently found that TMPRSS2:ERG fusion genes and PTEN loss, which are common in Western prostate cancers are infrequent in Chinese cases. As previous studies indicated a higher frequency of RAS and BRAF mutation rates in Eastern Asian than in Western prostate cancers and fusion genes involving the RAF family genes BRAF and RAF1 were recently identified in prostate cancer in the American population, we investigated BRAF and RAF1 alterations in Chinese prostate cancer. Using fluorescence in situ hybridization, we found that BRAF was truncated in five of 200 informative Chinese cases (2.5%) and that RAF1 was truncated in three of 204 informative cases (1.5%) and genomic rearrangements of these genes were significantly correlated with high Gleason scores (>7; P ",

keywords = "Aged, Base Sequence, China, DNA Mutational Analysis, Gene Dosage, Gene Rearrangement, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Male, Middle Aged, Molecular Sequence Data, Oncogene Proteins, Fusion, Prostatic Neoplasms, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf",

author = "Guoping Ren and Xiaoyan Liu and Xueying Mao and Yanling Zhang and Elzbieta Stankiewicz and Lucy Hylands and Rongrong Song and Berney, {Daniel M} and Jeremy Clark and Colin Cooper and Yong-Jie Lu",

note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",

year = "2012",

month = nov,

doi = "10.1002/gcc.21984",

language = "English",

volume = "51",

pages = "1014--23",

journal = "Genes, Chromosomes & Cancer",

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T1 - Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer

AU - Ren, Guoping

AU - Liu, Xiaoyan

AU - Mao, Xueying

AU - Zhang, Yanling

AU - Stankiewicz, Elzbieta

AU - Hylands, Lucy

AU - Song, Rongrong

AU - Berney, Daniel M

AU - Clark, Jeremy

AU - Cooper, Colin

AU - Lu, Yong-Jie

PY - 2012/11

Y1 - 2012/11

N2 - We recently found that TMPRSS2:ERG fusion genes and PTEN loss, which are common in Western prostate cancers are infrequent in Chinese cases. As previous studies indicated a higher frequency of RAS and BRAF mutation rates in Eastern Asian than in Western prostate cancers and fusion genes involving the RAF family genes BRAF and RAF1 were recently identified in prostate cancer in the American population, we investigated BRAF and RAF1 alterations in Chinese prostate cancer. Using fluorescence in situ hybridization, we found that BRAF was truncated in five of 200 informative Chinese cases (2.5%) and that RAF1 was truncated in three of 204 informative cases (1.5%) and genomic rearrangements of these genes were significantly correlated with high Gleason scores (>7; P

AB - We recently found that TMPRSS2:ERG fusion genes and PTEN loss, which are common in Western prostate cancers are infrequent in Chinese cases. As previous studies indicated a higher frequency of RAS and BRAF mutation rates in Eastern Asian than in Western prostate cancers and fusion genes involving the RAF family genes BRAF and RAF1 were recently identified in prostate cancer in the American population, we investigated BRAF and RAF1 alterations in Chinese prostate cancer. Using fluorescence in situ hybridization, we found that BRAF was truncated in five of 200 informative Chinese cases (2.5%) and that RAF1 was truncated in three of 204 informative cases (1.5%) and genomic rearrangements of these genes were significantly correlated with high Gleason scores (>7; P

KW - Aged

KW - Base Sequence

KW - China

KW - DNA Mutational Analysis

KW - Gene Dosage

KW - Gene Rearrangement

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Oncogene Proteins, Fusion

KW - Prostatic Neoplasms

KW - Proto-Oncogene Proteins B-raf

KW - Proto-Oncogene Proteins c-raf

U2 - 10.1002/gcc.21984

DO - 10.1002/gcc.21984

M3 - Article

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JO - Genes, Chromosomes & Cancer

JF - Genes, Chromosomes & Cancer

SN - 1045-2257

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