Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer

Guoping Ren, Xiaoyan Liu, Xueying Mao, Yanling Zhang, Elzbieta Stankiewicz, Lucy Hylands, Rongrong Song, Daniel M Berney, Jeremy Clark, Colin Cooper, Yong-Jie Lu

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33 Citations (Scopus)

Abstract

We recently found that TMPRSS2:ERG fusion genes and PTEN loss, which are common in Western prostate cancers are infrequent in Chinese cases. As previous studies indicated a higher frequency of RAS and BRAF mutation rates in Eastern Asian than in Western prostate cancers and fusion genes involving the RAF family genes BRAF and RAF1 were recently identified in prostate cancer in the American population, we investigated BRAF and RAF1 alterations in Chinese prostate cancer. Using fluorescence in situ hybridization, we found that BRAF was truncated in five of 200 informative Chinese cases (2.5%) and that RAF1 was truncated in three of 204 informative cases (1.5%) and genomic rearrangements of these genes were significantly correlated with high Gleason scores (>7; P
Original languageEnglish
Pages (from-to)1014-23
Number of pages10
JournalGenes, Chromosomes & Cancer
Volume51
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Aged
  • Base Sequence
  • China
  • DNA Mutational Analysis
  • Gene Dosage
  • Gene Rearrangement
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Oncogene Proteins, Fusion
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins c-raf

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