Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

Paul G. Wyatt, Michael J. Allen, Josie Chilcott, Christopher J. Gardner, David G. Livermore, Jackie E. Mordaunt, Fabrizio Nerozzi, Mamta Patel, Marion J. Perren, Gordon G. Weingarten, Shalia Shabbir, Patrick M. Woollard, Ping Zhou

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The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.
Original languageEnglish
Pages (from-to)1405-1411
Number of pages7
JournalBioorganic & Medicinal Chemistry Letters
Issue number10
Publication statusPublished - 20 May 2002


  • Animals
  • Benzofurans
  • Drug Design
  • Female
  • Humans
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Oxytocin
  • Rats
  • Receptors, Oxytocin
  • Structure-Activity Relationship
  • Uterine Contraction

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