Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

Paul G. Wyatt; Michael J. Allen; Josie Chilcott; Christopher J. Gardner; David G. Livermore; Jackie E. Mordaunt; Fabrizio Nerozzi; Mamta Patel; Marion J. Perren; Gordon G. Weingarten; Shalia Shabbir; Patrick M. Woollard; Ping Zhou

doi:10.1016/S0960-894X(02)00160-9

Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

Paul G. Wyatt, Michael J. Allen, Josie Chilcott, Christopher J. Gardner, David G. Livermore, Jackie E. Mordaunt, Fabrizio Nerozzi, Mamta Patel, Marion J. Perren, Gordon G. Weingarten, Shalia Shabbir, Patrick M. Woollard, Ping Zhou

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

Original language	English
Pages (from-to)	1405-1411
Number of pages	7
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00160-9
Publication status	Published - 20 May 2002

Keywords

Animals
Benzofurans
Drug Design
Female
Humans
Kinetics
Models, Molecular
Molecular Conformation
Oxytocin
Rats
Receptors, Oxytocin
Structure-Activity Relationship
Uterine Contraction

Access to Document

10.1016/S0960-894X(02)00160-9

Cite this

Wyatt, P. G., Allen, M. J., Chilcott, J., Gardner, C. J., Livermore, D. G., Mordaunt, J. E., Nerozzi, F., Patel, M., Perren, M. J., Weingarten, G. G., Shabbir, S., Woollard, P. M., & Zhou, P. (2002). Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12(10), 1405-1411. https://doi.org/10.1016/S0960-894X(02)00160-9

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keywords = "Animals, Benzofurans, Drug Design, Female, Humans, Kinetics, Models, Molecular, Molecular Conformation, Oxytocin, Rats, Receptors, Oxytocin, Structure-Activity Relationship, Uterine Contraction",

author = "Wyatt, {Paul G.} and Allen, {Michael J.} and Josie Chilcott and Gardner, {Christopher J.} and Livermore, {David G.} and Mordaunt, {Jackie E.} and Fabrizio Nerozzi and Mamta Patel and Perren, {Marion J.} and Weingarten, {Gordon G.} and Shalia Shabbir and Woollard, {Patrick M.} and Ping Zhou",

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Wyatt, PG, Allen, MJ, Chilcott, J, Gardner, CJ, Livermore, DG, Mordaunt, JE, Nerozzi, F, Patel, M, Perren, MJ, Weingarten, GG, Shabbir, S, Woollard, PM & Zhou, P 2002, 'Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives', Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1405-1411. https://doi.org/10.1016/S0960-894X(02)00160-9

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AU - Wyatt, Paul G.

AU - Allen, Michael J.

AU - Chilcott, Josie

AU - Gardner, Christopher J.

AU - Livermore, David G.

AU - Mordaunt, Jackie E.

AU - Nerozzi, Fabrizio

AU - Patel, Mamta

AU - Perren, Marion J.

AU - Weingarten, Gordon G.

AU - Shabbir, Shalia

AU - Woollard, Patrick M.

AU - Zhou, Ping

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KW - Benzofurans

KW - Drug Design

KW - Female

KW - Humans

KW - Kinetics

KW - Models, Molecular

KW - Molecular Conformation

KW - Oxytocin

KW - Rats

KW - Receptors, Oxytocin

KW - Structure-Activity Relationship

KW - Uterine Contraction

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DO - 10.1016/S0960-894X(02)00160-9

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