Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives

Paul G Wyatt, Michael J Allen, Josie Chilcott, Alison Foster, David G Livermore, Jackie E Mordaunt, Jan Scicinski, Patrick M Woollard

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Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.
Original languageEnglish
Pages (from-to)1399-404
Number of pages6
JournalBioorganic & Medicinal Chemistry Letters
Issue number10
Publication statusPublished - 20 May 2002


  • Animals
  • Benzofurans
  • Biological Availability
  • Dogs
  • Drug Design
  • Humans
  • Indoles
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Oxytocin
  • Receptors, Oxytocin
  • Structure-Activity Relationship

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