IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

Mark Tremelling; Fraser Cummings; Sheila A Fisher; John Mansfield; Rhian Gwilliam; Andrew Keniry; Elaine R Nimmo; Hazel Drummond; Clive M Onnie; Natalie J Prescott; Jeremy Sanderson; Francesca Bredin; Carlo Berzuini; Alastair Forbes; Cathryn M Lewis; Lon Cardon; Panos Deloukas; Derek Jewell; Christopher G Mathew; Miles Parkes; Jack Satsangi

doi:10.1053/j.gastro.2007.02.051

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

Mark Tremelling, Fraser Cummings, Sheila A Fisher, John Mansfield, Rhian Gwilliam, Andrew Keniry, Elaine R Nimmo, Hazel Drummond, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Francesca Bredin, Carlo Berzuini, Alastair Forbes, Cathryn M Lewis, Lon Cardon, Panos Deloukas, Derek Jewell, Christopher G Mathew, Miles ParkesJack Satsangi

Research output: Contribution to journal › Article › peer-review

166 Citations (SciVal)

Abstract

Identification of inflammatory bowel disease (IBD) susceptibility genes is key to understanding pathogenic mechanisms. Recently, the North American IBD Genetics Consortium provided compelling evidence for an association between ileal Crohn's disease (CD) and the IL23R gene using genome-wide association scanning. External replication is a priority, both to confirm this finding in other populations and to validate this new technique. We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15.

Original language	English
Pages (from-to)	1657-64
Number of pages	8
Journal	Gastroenterology
Volume	132
Issue number	5
DOIs	https://doi.org/10.1053/j.gastro.2007.02.051
Publication status	Published - May 2007

Keywords

Adult
Case-Control Studies
Cohort Studies
Colitis, Ulcerative
Crohn Disease
England
Epistasis, Genetic
Female
Genetic Predisposition to Disease
Humans
Inflammatory Bowel Diseases
Male
Nod2 Signaling Adaptor Protein
Phenotype
Polymorphism, Single Nucleotide
Receptors, Interleukin
Risk Factors
Scotland

Access to Document

10.1053/j.gastro.2007.02.051

Cite this

Tremelling, M., Cummings, F., Fisher, S. A., Mansfield, J., Gwilliam, R., Keniry, A., Nimmo, E. R., Drummond, H., Onnie, C. M., Prescott, N. J., Sanderson, J., Bredin, F., Berzuini, C., Forbes, A., Lewis, C. M., Cardon, L., Deloukas, P., Jewell, D., Mathew, C. G., ... Satsangi, J. (2007). IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology, 132(5), 1657-64. https://doi.org/10.1053/j.gastro.2007.02.051

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title = "IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease",

abstract = "Identification of inflammatory bowel disease (IBD) susceptibility genes is key to understanding pathogenic mechanisms. Recently, the North American IBD Genetics Consortium provided compelling evidence for an association between ileal Crohn's disease (CD) and the IL23R gene using genome-wide association scanning. External replication is a priority, both to confirm this finding in other populations and to validate this new technique. We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15.",

keywords = "Adult, Case-Control Studies, Cohort Studies, Colitis, Ulcerative, Crohn Disease, England, Epistasis, Genetic, Female, Genetic Predisposition to Disease, Humans, Inflammatory Bowel Diseases, Male, Nod2 Signaling Adaptor Protein, Phenotype, Polymorphism, Single Nucleotide, Receptors, Interleukin, Risk Factors, Scotland",

author = "Mark Tremelling and Fraser Cummings and Fisher, {Sheila A} and John Mansfield and Rhian Gwilliam and Andrew Keniry and Nimmo, {Elaine R} and Hazel Drummond and Onnie, {Clive M} and Prescott, {Natalie J} and Jeremy Sanderson and Francesca Bredin and Carlo Berzuini and Alastair Forbes and Lewis, {Cathryn M} and Lon Cardon and Panos Deloukas and Derek Jewell and Mathew, {Christopher G} and Miles Parkes and Jack Satsangi",

year = "2007",

month = may,

doi = "10.1053/j.gastro.2007.02.051",

language = "English",

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pages = "1657--64",

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Tremelling, M, Cummings, F, Fisher, SA, Mansfield, J, Gwilliam, R, Keniry, A, Nimmo, ER, Drummond, H, Onnie, CM, Prescott, NJ, Sanderson, J, Bredin, F, Berzuini, C, Forbes, A, Lewis, CM, Cardon, L, Deloukas, P, Jewell, D, Mathew, CG, Parkes, M & Satsangi, J 2007, 'IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease', Gastroenterology, vol. 132, no. 5, pp. 1657-64. https://doi.org/10.1053/j.gastro.2007.02.051

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T1 - IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

AU - Tremelling, Mark

AU - Cummings, Fraser

AU - Fisher, Sheila A

AU - Mansfield, John

AU - Gwilliam, Rhian

AU - Keniry, Andrew

AU - Nimmo, Elaine R

AU - Drummond, Hazel

AU - Onnie, Clive M

AU - Prescott, Natalie J

AU - Sanderson, Jeremy

AU - Bredin, Francesca

AU - Berzuini, Carlo

AU - Forbes, Alastair

AU - Lewis, Cathryn M

AU - Cardon, Lon

AU - Deloukas, Panos

AU - Jewell, Derek

AU - Mathew, Christopher G

AU - Parkes, Miles

AU - Satsangi, Jack

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AB - Identification of inflammatory bowel disease (IBD) susceptibility genes is key to understanding pathogenic mechanisms. Recently, the North American IBD Genetics Consortium provided compelling evidence for an association between ileal Crohn's disease (CD) and the IL23R gene using genome-wide association scanning. External replication is a priority, both to confirm this finding in other populations and to validate this new technique. We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15.

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KW - Case-Control Studies

KW - Cohort Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - England

KW - Epistasis, Genetic

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Male

KW - Nod2 Signaling Adaptor Protein

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Receptors, Interleukin

KW - Risk Factors

KW - Scotland

U2 - 10.1053/j.gastro.2007.02.051

DO - 10.1053/j.gastro.2007.02.051

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VL - 132

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JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

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