Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease

Polychronis Pavlidis; Ourania Romanidou; Dirk Roggenbuck; Maria G. Mytilinaiou; Faris Al-Sulttan; Christos Liaskos; Daniel S. Smyk; Andreas L. Koutsoumpas; Eirini I. Rigopoulou; Karsten Conrad; Alastair Forbes; Dimitrios P. Bogdanos

doi:10.1155/2012/640835

Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease

Polychronis Pavlidis, Ourania Romanidou, Dirk Roggenbuck, Maria G. Mytilinaiou, Faris Al-Sulttan, Christos Liaskos, Daniel S. Smyk, Andreas L. Koutsoumpas, Eirini I. Rigopoulou, Karsten Conrad, Alastair Forbes, Dimitrios P. Bogdanos

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 is also present on the apical surface of microfold (M) intestinal cells. As the colon lacks GP2-rich M cells, we assumed that patients with colonic CD are seronegative for anti-GP2. Anti-GP2 antibodies were tested in 225 CDs, including 45 patients with colonic location (L2), 45 with terminal ileum (L1) and 135 with ileocolonic involvement; 225 patients with ulcerative colitis (UC) were also tested. Anti-GP2 reactivity was detected in 59 (26.2%) CDs and 15 (6.7%) UCs (P

Original language	English
Article number	640835
Journal	Clinical & Developmental Immunology
Volume	2012
DOIs	https://doi.org/10.1155/2012/640835
Publication status	Published - 2012

Keywords

Adult
Autoantibodies
Autoantigens
Colitis, Ulcerative
Crohn Disease
Female
GPI-Linked Proteins
Humans
Ileitis
Immunoglobulin G
Inflammation
Inflammatory Bowel Diseases
Male
Membrane Glycoproteins
Middle Aged
Pancreas

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Cite this

Pavlidis, P., Romanidou, O., Roggenbuck, D., Mytilinaiou, M. G., Al-Sulttan, F., Liaskos, C., Smyk, D. S., Koutsoumpas, A. L., Rigopoulou, E. I., Conrad, K., Forbes, A., & Bogdanos, D. P. (2012). Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease. Clinical & Developmental Immunology, 2012, [640835]. https://doi.org/10.1155/2012/640835

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title = "Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease",

abstract = "Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 is also present on the apical surface of microfold (M) intestinal cells. As the colon lacks GP2-rich M cells, we assumed that patients with colonic CD are seronegative for anti-GP2. Anti-GP2 antibodies were tested in 225 CDs, including 45 patients with colonic location (L2), 45 with terminal ileum (L1) and 135 with ileocolonic involvement; 225 patients with ulcerative colitis (UC) were also tested. Anti-GP2 reactivity was detected in 59 (26.2%) CDs and 15 (6.7%) UCs (P ",

keywords = "Adult, Autoantibodies, Autoantigens, Colitis, Ulcerative, Crohn Disease, Female, GPI-Linked Proteins, Humans, Ileitis, Immunoglobulin G, Inflammation, Inflammatory Bowel Diseases, Male, Membrane Glycoproteins, Middle Aged, Pancreas",

author = "Polychronis Pavlidis and Ourania Romanidou and Dirk Roggenbuck and Mytilinaiou, {Maria G.} and Faris Al-Sulttan and Christos Liaskos and Smyk, {Daniel S.} and Koutsoumpas, {Andreas L.} and Rigopoulou, {Eirini I.} and Karsten Conrad and Alastair Forbes and Bogdanos, {Dimitrios P.}",

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Pavlidis, P, Romanidou, O, Roggenbuck, D, Mytilinaiou, MG, Al-Sulttan, F, Liaskos, C, Smyk, DS, Koutsoumpas, AL, Rigopoulou, EI, Conrad, K, Forbes, A & Bogdanos, DP 2012, 'Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease', Clinical & Developmental Immunology, vol. 2012, 640835. https://doi.org/10.1155/2012/640835

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AU - Romanidou, Ourania

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AU - Mytilinaiou, Maria G.

AU - Al-Sulttan, Faris

AU - Liaskos, Christos

AU - Smyk, Daniel S.

AU - Koutsoumpas, Andreas L.

AU - Rigopoulou, Eirini I.

AU - Conrad, Karsten

AU - Forbes, Alastair

AU - Bogdanos, Dimitrios P.

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KW - Immunoglobulin G

KW - Inflammation

KW - Inflammatory Bowel Diseases

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