Ileo-caecal ulceration associated with the use of diclofenac slow release

N Hudson, M J Wilkinson, A J Swannell, R J Steele, C J Hawkey

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28 Citations (Scopus)


A 38-year-old man with seropositive arthropathy on long-standing treatment with diclofenac slow release presented with abdominal pain, diarrhoea and anaemia. Upper gastrointestinal endoscopy and barium series were unremarkable. Five months later he presented with a right iliac fossa mass. Investigations revealed discrete ulceration in the terminal ileum and caecum confirmed at laparotomy. Other possible causes of intestinal ulceration were excluded suggesting a diagnosis of non-steroidal anti-inflammatory drug associated intestinal ulceration.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalAlimentary Pharmacology and Therapeutics
Issue number2
Publication statusPublished - Apr 1993


  • Adult
  • Delayed-Action Preparations
  • Diclofenac
  • Humans
  • Intestinal Diseases
  • Joint Diseases
  • Male
  • Ulcer

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