TY - JOUR
T1 - Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
AU - Reynolds, Catherine J.
AU - Pade, Corinna
AU - Gibbons, Joseph M.
AU - Otter, Ashley D.
AU - Lin, Kai-Min
AU - Sandoval, Diana Muñoz
AU - Pieper, Franziska P.
AU - Butler, David K.
AU - Liu, Siyi
AU - Joy, George
AU - Forooghi, Nasim
AU - Treibel, Thomas A.
AU - Manisty, Charlotte
AU - Moon, James C.
AU - COVIDsortium Investigators
AU - COVIDsortium Immune Correlates Network
AU - Semper, Amanda
AU - Brooks, Tim
AU - McKnight, Áine
AU - Altmann, Daniel M.
AU - Boyton, Rosemary J.
A2 - Hickling, Lauren M.
N1 - Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper or the supplementary materials. The SARS-CoV-2 Wuhan Hu-1 Human 2019-nCoV, B.1.351, P.1, B.1.617.2, and B.1.1.529 isolates were obtained under material agreements with EVAg, France. The SARS-CoV-2 B.1.1.7 isolate was obtained under a material agreement with NIBSC, UK.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
AB - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
UR - http://www.scopus.com/inward/record.url?scp=85132254530&partnerID=8YFLogxK
U2 - 10.1126/science.abq1841
DO - 10.1126/science.abq1841
M3 - Article
AN - SCOPUS:85132254530
SN - 0036-8075
VL - 377
JO - Science
JF - Science
IS - 6603
M1 - eabq1841
ER -
