Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer

Sakunthala C Kudahetti; Gabrielle Fisher; Laurence Ambroisine; David Prowse; Michael W Kattan; Christopher S Foster; Henrik Møller; Tim Oliver; Anne Fletcher; Colin Cooper; Victor Reuter; Peter Scardino; Jack Cuzick; Daniel M Berney; Transatlantic Prostate Group

doi:10.3109/00313025.2010.508788

Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer

Sakunthala C Kudahetti
, Gabrielle Fisher
, Laurence Ambroisine
, David Prowse
, Michael W Kattan
, Christopher S Foster
, Henrik Møller
, Tim Oliver
, Anne Fletcher
, Colin Cooper
, Victor Reuter
, Peter Scardino
, Jack Cuzick
, Daniel M Berney
, Transatlantic Prostate Group

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle markers, Rb, p21 and p16, would provide helpful prognostic information in a well characterised series of prostate cancers which were clinically localised and treated conservatively.

Original language	English
Pages (from-to)	519-23
Number of pages	5
Journal	Plant Pathology
Volume	42
Issue number	6
DOIs	https://doi.org/10.3109/00313025.2010.508788
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Neoplasm Staging
Prognosis
Prostatic Neoplasms
Retinoblastoma Protein
Tissue Array Analysis
Treatment Outcome
Tumor Markers, Biological

Access to Document

10.3109/00313025.2010.508788

Cite this

Kudahetti, S. C., Fisher, G., Ambroisine, L., Prowse, D., Kattan, M. W., Foster, C. S., Møller, H., Oliver, T., Fletcher, A., Cooper, C., Reuter, V., Scardino, P., Cuzick, J., Berney, D. M., & Transatlantic Prostate Group (2010). Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer. Plant Pathology, 42(6), 519-23. https://doi.org/10.3109/00313025.2010.508788

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title = "Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer",

abstract = "Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle markers, Rb, p21 and p16, would provide helpful prognostic information in a well characterised series of prostate cancers which were clinically localised and treated conservatively.",

keywords = "Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Neoplasm Staging, Prognosis, Prostatic Neoplasms, Retinoblastoma Protein, Tissue Array Analysis, Treatment Outcome, Tumor Markers, Biological",

author = "Kudahetti, \{Sakunthala C\} and Gabrielle Fisher and Laurence Ambroisine and David Prowse and Kattan, \{Michael W\} and Foster, \{Christopher S\} and Henrik M{\o}ller and Tim Oliver and Anne Fletcher and Colin Cooper and Victor Reuter and Peter Scardino and Jack Cuzick and Berney, \{Daniel M\} and \{Transatlantic Prostate Group\}",

year = "2010",

doi = "10.3109/00313025.2010.508788",

language = "English",

volume = "42",

pages = "519--23",

journal = "Plant Pathology",

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publisher = "Wiley",

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}

Kudahetti, SC, Fisher, G, Ambroisine, L, Prowse, D, Kattan, MW, Foster, CS, Møller, H, Oliver, T, Fletcher, A, Cooper, C, Reuter, V, Scardino, P, Cuzick, J, Berney, DM & Transatlantic Prostate Group 2010, 'Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer', Plant Pathology, vol. 42, no. 6, pp. 519-23. https://doi.org/10.3109/00313025.2010.508788

TY - JOUR

T1 - Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer

AU - Kudahetti, Sakunthala C

AU - Fisher, Gabrielle

AU - Ambroisine, Laurence

AU - Prowse, David

AU - Kattan, Michael W

AU - Foster, Christopher S

AU - Møller, Henrik

AU - Oliver, Tim

AU - Fletcher, Anne

AU - Cooper, Colin

AU - Reuter, Victor

AU - Scardino, Peter

AU - Cuzick, Jack

AU - Berney, Daniel M

AU - Transatlantic Prostate Group

PY - 2010

Y1 - 2010

N2 - Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle markers, Rb, p21 and p16, would provide helpful prognostic information in a well characterised series of prostate cancers which were clinically localised and treated conservatively.

AB - Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle markers, Rb, p21 and p16, would provide helpful prognostic information in a well characterised series of prostate cancers which were clinically localised and treated conservatively.

KW - Cyclin-Dependent Kinase Inhibitor p16

KW - Cyclin-Dependent Kinase Inhibitor p21

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Male

KW - Neoplasm Staging

KW - Prognosis

KW - Prostatic Neoplasms

KW - Retinoblastoma Protein

KW - Tissue Array Analysis

KW - Treatment Outcome

KW - Tumor Markers, Biological

U2 - 10.3109/00313025.2010.508788

DO - 10.3109/00313025.2010.508788

M3 - Article

C2 - 20854069

SN - 0032-0862

VL - 42

SP - 519

EP - 523

JO - Plant Pathology

JF - Plant Pathology

IS - 6

ER -