Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Abdul R Maher, Sayqa Arif, Melanie Madhani, Khalid Abozguia, Ibrar Ahmed, Bernadette O Fernandez, Martin Feelisch, A G O'Sullivan, Arthur Christopoulos, Aaron L Sverdlov, Doan Ngo, Rustem Dautov, Philip E James, John D Horowitz, Michael P Frenneaux

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Nitrite (NO₂⁻) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂⁻ in healthy volunteers and patients with stable congestive heart failure (CHF).
Original languageEnglish
Pages (from-to)659-70
Number of pages12
JournalBritish Journal of Pharmacology
Issue number3
Publication statusPublished - Jun 2013


  • Aged
  • Brachial Artery
  • Cohort Studies
  • Drug Tolerance
  • Female
  • Forearm
  • Heart Failure
  • Hemodynamics
  • Humans
  • In Vitro Techniques
  • Infusions, Intra-Arterial
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Nitric Oxide
  • Nitroglycerin
  • Oxidative Stress
  • Regional Blood Flow
  • Saphenous Vein
  • Sodium Nitrite
  • Vasodilation
  • Vasodilator Agents
  • Vasomotor System

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