Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Abdul R Maher; Sayqa Arif; Melanie Madhani; Khalid Abozguia; Ibrar Ahmed; Bernadette O Fernandez; Martin Feelisch; A G O'Sullivan; Arthur Christopoulos; Aaron L Sverdlov; Doan Ngo; Rustem Dautov; Philip E James; John D Horowitz; Michael P Frenneaux

doi:10.1111/bph.12152

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Abdul R Maher
, Sayqa Arif
, Melanie Madhani
, Khalid Abozguia
, Ibrar Ahmed
, Bernadette O Fernandez
, Martin Feelisch
, A G O'Sullivan
, Arthur Christopoulos
, Aaron L Sverdlov
, Doan Ngo
, Rustem Dautov
, Philip E James
, John D Horowitz
, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Nitrite (NO₂⁻) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂⁻ in healthy volunteers and patients with stable congestive heart failure (CHF).

Original language	English
Pages (from-to)	659-70
Number of pages	12
Journal	British Journal of Pharmacology
Volume	169
Issue number	3
DOIs	https://doi.org/10.1111/bph.12152
Publication status	Published - Jun 2013

Keywords

Aged
Brachial Artery
Cohort Studies
Drug Tolerance
Female
Forearm
Heart Failure
Hemodynamics
Humans
In Vitro Techniques
Infusions, Intra-Arterial
Male
Metabolic Clearance Rate
Middle Aged
Nitric Oxide
Nitroglycerin
Oxidative Stress
Regional Blood Flow
Saphenous Vein
Sodium Nitrite
Vasodilation
Vasodilator Agents
Vasomotor System

Access to Document

10.1111/bph.12152

Cite this

Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., Feelisch, M., O'Sullivan, A. G., Christopoulos, A., Sverdlov, A. L., Ngo, D., Dautov, R., James, P. E., Horowitz, J. D., & Frenneaux, M. P. (2013). Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. British Journal of Pharmacology, 169(3), 659-70. https://doi.org/10.1111/bph.12152

@article{9414f4c091ed42a39baf852a0f06cdf4,

title = "Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite",

abstract = "Nitrite (NO₂⁻) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂⁻ in healthy volunteers and patients with stable congestive heart failure (CHF).",

keywords = "Aged, Brachial Artery, Cohort Studies, Drug Tolerance, Female, Forearm, Heart Failure, Hemodynamics, Humans, In Vitro Techniques, Infusions, Intra-Arterial, Male, Metabolic Clearance Rate, Middle Aged, Nitric Oxide, Nitroglycerin, Oxidative Stress, Regional Blood Flow, Saphenous Vein, Sodium Nitrite, Vasodilation, Vasodilator Agents, Vasomotor System",

author = "Maher, \{Abdul R\} and Sayqa Arif and Melanie Madhani and Khalid Abozguia and Ibrar Ahmed and Fernandez, \{Bernadette O\} and Martin Feelisch and O'Sullivan, \{A G\} and Arthur Christopoulos and Sverdlov, \{Aaron L\} and Doan Ngo and Rustem Dautov and James, \{Philip E\} and Horowitz, \{John D\} and Frenneaux, \{Michael P\}",

note = "{\textcopyright} 2013 The Authors. British Journal of Pharmacology {\textcopyright} 2013 The British Pharmacological Society.",

year = "2013",

month = jun,

doi = "10.1111/bph.12152",

language = "English",

volume = "169",

pages = "659--70",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "Wiley",

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Maher, AR, Arif, S, Madhani, M, Abozguia, K, Ahmed, I, Fernandez, BO, Feelisch, M, O'Sullivan, AG, Christopoulos, A, Sverdlov, AL, Ngo, D, Dautov, R, James, PE, Horowitz, JD & Frenneaux, MP 2013, 'Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite', British Journal of Pharmacology, vol. 169, no. 3, pp. 659-70. https://doi.org/10.1111/bph.12152

TY - JOUR

T1 - Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

AU - Maher, Abdul R

AU - Arif, Sayqa

AU - Madhani, Melanie

AU - Abozguia, Khalid

AU - Ahmed, Ibrar

AU - Fernandez, Bernadette O

AU - Feelisch, Martin

AU - O'Sullivan, A G

AU - Christopoulos, Arthur

AU - Sverdlov, Aaron L

AU - Ngo, Doan

AU - Dautov, Rustem

AU - James, Philip E

AU - Horowitz, John D

AU - Frenneaux, Michael P

PY - 2013/6

Y1 - 2013/6

N2 - Nitrite (NO₂⁻) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂⁻ in healthy volunteers and patients with stable congestive heart failure (CHF).

AB - Nitrite (NO₂⁻) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO₂⁻ in healthy volunteers and patients with stable congestive heart failure (CHF).

KW - Aged

KW - Brachial Artery

KW - Cohort Studies

KW - Drug Tolerance

KW - Female

KW - Forearm

KW - Heart Failure

KW - Hemodynamics

KW - Humans

KW - In Vitro Techniques

KW - Infusions, Intra-Arterial

KW - Male

KW - Metabolic Clearance Rate

KW - Middle Aged

KW - Nitric Oxide

KW - Nitroglycerin

KW - Oxidative Stress

KW - Regional Blood Flow

KW - Saphenous Vein

KW - Sodium Nitrite

KW - Vasodilation

KW - Vasodilator Agents

KW - Vasomotor System

U2 - 10.1111/bph.12152

DO - 10.1111/bph.12152

M3 - Article

C2 - 23472879

SN - 0007-1188

VL - 169

SP - 659

EP - 670

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 3

ER -