Projects per year
Abstract
Purpose of Review: This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.
Recent Findings: Recent evidence indicates that plant-derived flavonoids may exert powerful actions on mammalian cognition and protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects of flavonoids have been suggested to be due to interactions with the cellular and molecular architecture of brain regions responsible for memory.
Summary: Mechanisms for the beneficial effects of flavonoids on age-related cognitive decline and dementia are discussed, including modulating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation, promoting vascular effects capable of stimulating new nerve cell growth in the hippocampus, bidirectional interactions with gut microbiota and attenuating the extracellular accumulation of pathological proteins. These processes are known to be important in maintaining optimal neuronal function and preventing age-related cognitive decline and neurodegeneration.
Recent Findings: Recent evidence indicates that plant-derived flavonoids may exert powerful actions on mammalian cognition and protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects of flavonoids have been suggested to be due to interactions with the cellular and molecular architecture of brain regions responsible for memory.
Summary: Mechanisms for the beneficial effects of flavonoids on age-related cognitive decline and dementia are discussed, including modulating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation, promoting vascular effects capable of stimulating new nerve cell growth in the hippocampus, bidirectional interactions with gut microbiota and attenuating the extracellular accumulation of pathological proteins. These processes are known to be important in maintaining optimal neuronal function and preventing age-related cognitive decline and neurodegeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 49–57 |
| Number of pages | 9 |
| Journal | Current Nutrition Reports |
| Volume | 7 |
| Issue number | 2 |
| Early online date | 27 Apr 2018 |
| DOIs | |
| Publication status | Published - Jun 2018 |
Keywords
- Polyphenols
- Memory
- Alzheimer’s disease
- Signalling pathways
- Microbiome
Profiles
-
Michael Hornberger
- Norwich Medical School - Professor of Applied Dementia Research
- Norwich Institute for Healthy Aging - Member
- Lifespan Health - Member
- Mental Health - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
-
Michael Muller
- Norwich Medical School - Emeritus Professor, Professor of Nutrigenomics and Systems Nutrition
- Norwich Institute for Healthy Aging - Member
- Metabolic Health - Member
- Gastroenterology and Gut Biology - Member
- Nutrition and Preventive Medicine - Member
Person: Honorary, Other related - academic, Research Group Member, Research Centre Member
-
David Vauzour
- Norwich Medical School - Associate Professor in Molecular Nutrition
- Norwich Institute for Healthy Aging - Member
- Metabolic Health - Member
- Nutrition and Preventive Medicine - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
Projects
- 1 Finished
-
The impact of Cranberries on the gut microbiota and cognition in “at-genetic-risk” Alzheimer’s disease participants: a double blind, randomised placebo controlled, parallel group study.
Vauzour, D., Hornberger, M., Jurkowski, V., Muller, M. & Narbad, A.
1/09/17 → 30/06/22
Project: Research