Impact of lymph node ratio in the colorectal cancer staging system

Paolo Del Rio, Paolo Dell'Abate, Cinzia Papadia, Adriana Angeletta, Chiara Montana, Gioacchino Iapichino, Mario Sianesi

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5 Citations (Scopus)


AIM: Some researchers have proposed the Lymph Node Ratio (LNR) as a prognostic index for post-surgical colorectal cancer follow up. 

MATERIAL AND METHOD: Two hundred patients with colorectal cancer (ratio F/M of 2:1) were studied. Patients were divided in subgroups according to N-stage and LNR score, subgroups of LNR were made on quartiles. For each subgroup 5 year survival rate was calculated and comparison between groups was carried out. 

RESULTS: There were 104 patients on N0, 38 on N1 and 58 on N2 stage. Survival rate at 5 years was 61.30% for the NO subgroup, 18.70% for the N1 subgroup, and 12.31% for the N2 subgroup (Fig. 1). The most significant p value, was reported between N0 and N1 as well as between N0 and N2 subgroup (p=0.001). Nodes positive were 44 a LNR ranging from 1% to 25% (1% < LNR < 25%); 24 patients from 26% to 50% (26% < LNR < 50%). In 6 patients LNR was ranging from 51% to 75% (51% < LNR 75%) and in 8 patients from 76% to 100% (76% < LNR 100%); overall survival rate in different quartiles was respectively 27.12%, 9.38%, 16.67% and 1.56%. 

CONCLUSION: LNR is a reliable prognostic index in post surgical colorectal cancer staging. 

Original languageEnglish
Pages (from-to)399-403
Number of pages6
JournalAnnali Italiani di Chirurgia
Issue number5
Publication statusPublished - Oct 2012


  • Aged
  • Colorectal Neoplasms
  • Female
  • Humans
  • Lymph Nodes
  • Lymphatic Metastasis
  • Male
  • Neoplasm Staging
  • Retrospective Studies

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