Non-uniform mechanical strain can be easily induced at the interface of a piezoelectric semiconductive (PS) PN junction with variable cross sections by using piezoactive acoustic waves, and thus produces a giant piezoelectric field to significantly enhance the piezotronic effect. For revealing the piezotronic performance modulation in the non-uniform PS PN junction, the electromechanical field under a pair of applied end mechanical forces is studied from perspectives of theoretical analysis and numerical simulations. A one-dimensional linearized model for the PS fiber is established, which is applied for the mechanical analysis of a selected profile with the cross section varying in a specific quadratic function. Numerical results indicate that the acoustoelectric fields in the space charge region of the non-uniform PS PN junction are more sensitive to the applied mechanical forces, compared with that of the uniform junction, especially for a heterogeneous PN junction. Furthermore, the current-voltage relations of a necking PS PN junction can be modulated more easily by the end mechanical forces. Both qualitative conclusions and quantitative results can offer guidance for the piezotronic device design.