Impacts of molecular structure on nucleic acid–protein interactions

Interactions between nucleic acids and proteins are some of the most important interactions in biology because they are the cornerstones for fundamental biological processes, such as replication, transcription, and recombination. Nucleic acids can adopt a wide range of structural conformations and this structural flexibility plays critical roles in their interactions with proteins [1]. This Special Issue of the International Journal of Molecular Sciences reports on diverse representatives of such interactions (Figure 1) across a wide range of biological systems.