Impaired energetics in heart failure - a new therapeutic target

Julian O M Ormerod, Houman Ashrafian, Michael P Frenneaux

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Heart failure is a syndrome of huge and growing importance worldwide. It is widely accepted that the energy status of the myocardium in heart failure is impaired, irrespective of etiology. Agents which modify cardiac substrate utilisation have the potential to ameliorate this energy deficiency by increasing cardiac mechanical efficiency. This may represent a new therapeutic paradigm in heart failure. In this review we discuss existing and new agents that alter cardiac substrate use and summarise the data on clinical efficacy.
Original languageEnglish
Pages (from-to)264-74
Number of pages11
JournalPharmacology & Therapeutics
Issue number3
Publication statusPublished - Sep 2008


  • Animals
  • Carbohydrate Metabolism
  • Energy Metabolism
  • Heart Failure
  • Humans
  • Models, Biological
  • Myocardium
  • Oxidation-Reduction

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