Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor

M W N Harbord; D J B Marks; A Forbes; S L Bloom; R M Day; A W Segal

doi:10.1111/j.1365-2036.2006.03016.x

Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor

M W N Harbord, D J B Marks, A Forbes, S L Bloom, R M Day, A W Segal

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.

Original language	English
Pages (from-to)	651-660
Number of pages	10
Journal	Alimentary Pharmacology and Therapeutics
Volume	24
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2036.2006.03016.x
Publication status	Published - 15 Aug 2006

Keywords

Adult
Aged
Chemokines
Chemotaxis, Leukocyte
Crohn Disease
Female
Granulocyte Colony-Stimulating Factor
Humans
Male
Middle Aged
Neutrophils

Access to Document

10.1111/j.1365-2036.2006.03016.x

Cite this

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title = "Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor",

abstract = "Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.",

keywords = "Adult, Aged, Chemokines, Chemotaxis, Leukocyte, Crohn Disease, Female, Granulocyte Colony-Stimulating Factor, Humans, Male, Middle Aged, Neutrophils",

author = "Harbord, {M W N} and Marks, {D J B} and A Forbes and Bloom, {S L} and Day, {R M} and Segal, {A W}",

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AU - Harbord, M W N

AU - Marks, D J B

AU - Forbes, A

AU - Bloom, S L

AU - Day, R M

AU - Segal, A W

PY - 2006/8/15

Y1 - 2006/8/15

N2 - Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.

AB - Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.

KW - Adult

KW - Aged

KW - Chemokines

KW - Chemotaxis, Leukocyte

KW - Crohn Disease

KW - Female

KW - Granulocyte Colony-Stimulating Factor

KW - Humans

KW - Male

KW - Middle Aged

KW - Neutrophils

U2 - 10.1111/j.1365-2036.2006.03016.x

DO - 10.1111/j.1365-2036.2006.03016.x

M3 - Article

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SN - 0269-2813

VL - 24

SP - 651

EP - 660

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 4

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