Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.
|Number of pages||10|
|Journal||Alimentary Pharmacology and Therapeutics|
|Publication status||Published - 15 Aug 2006|
- Chemotaxis, Leukocyte
- Crohn Disease
- Granulocyte Colony-Stimulating Factor
- Middle Aged