Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor

M W N Harbord, D J B Marks, A Forbes, S L Bloom, R M Day, A W Segal

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Defective neutrophil recruitment has been described as a primary pathogenic abnormality in Crohn's disease. Cantharidin-induced blisters provide a novel investigative tool to assess cellular influx and inflammatory mediator production during acute inflammation and allows the effects of therapy on these parameters to be measured.
Original languageEnglish
Pages (from-to)651-660
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Volume24
Issue number4
DOIs
Publication statusPublished - 15 Aug 2006

Keywords

  • Adult
  • Aged
  • Chemokines
  • Chemotaxis, Leukocyte
  • Crohn Disease
  • Female
  • Granulocyte Colony-Stimulating Factor
  • Humans
  • Male
  • Middle Aged
  • Neutrophils

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