Improved syntheses of n-substituted nitroimidazoles

M. Searcey; P. L. Pye; J. B. Lee

doi:10.1080/00397918908054539

Improved syntheses of n-substituted nitroimidazoles

M. Searcey, P. L. Pye, J. B. Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Nitroimidazoles are of considerable medical and potential agricultural interest as chemotherapeutic agents and potential biocides. The standard route to many 1-substituted nitroimidazoles is the condensation of the conjugate base of the nitroimidazole in a suitable (usually protic) solvent with the appropriate halo compound. Except in a few favourable instances yields are generally low1.

Original language	English
Pages (from-to)	1309-1315
Number of pages	7
Journal	Synthetic Communications
Volume	19
Issue number	7-8
DOIs	https://doi.org/10.1080/00397918908054539
Publication status	Published - 1 Apr 1989

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10.1080/00397918908054539

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abstract = "Nitroimidazoles are of considerable medical and potential agricultural interest as chemotherapeutic agents and potential biocides. The standard route to many 1-substituted nitroimidazoles is the condensation of the conjugate base of the nitroimidazole in a suitable (usually protic) solvent with the appropriate halo compound. Except in a few favourable instances yields are generally low1.",

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AB - Nitroimidazoles are of considerable medical and potential agricultural interest as chemotherapeutic agents and potential biocides. The standard route to many 1-substituted nitroimidazoles is the condensation of the conjugate base of the nitroimidazole in a suitable (usually protic) solvent with the appropriate halo compound. Except in a few favourable instances yields are generally low1.

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Improved syntheses of n-substituted nitroimidazoles

Abstract

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