Improving mechanical properties of crystalline solids by cocrystal formation: New compressible forms of paracetamol

Shyam Karki; Tomislav Friščić; Laszlo Fabian; Peter R. Laity; Graeme M. Day; William Jones

doi:10.1002/adma.200900533

Improving mechanical properties of crystalline solids by cocrystal formation: New compressible forms of paracetamol

Shyam Karki, Tomislav Friščić, Laszlo Fabian, Peter R. Laity, Graeme M. Day, William Jones

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

467 Citations (Scopus)

Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

Original language	English
Pages (from-to)	3905-3909
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	38-39
DOIs	https://doi.org/10.1002/adma.200900533
Publication status	Published - 19 Oct 2009

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10.1002/adma.200900533

Cite this

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title = "Improving mechanical properties of crystalline solids by cocrystal formation: New compressible forms of paracetamol",

abstract = "Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.",

author = "Shyam Karki and Tomislav Fri{\v s}{\v c}i{\'c} and Laszlo Fabian and Laity, {Peter R.} and Day, {Graeme M.} and William Jones",

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AU - Friščić, Tomislav

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AU - Laity, Peter R.

AU - Day, Graeme M.

AU - Jones, William

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AB - Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

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DO - 10.1002/adma.200900533

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