In two minds: executive functioning versus theory of mind in behavioural variant frontotemporal dementia

Maxime Bertoux, Claire O'Callaghan, Bruno Dubois, Michael Hornberger

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
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Abstract

Background: The relationship of executive function (EF) and theory of mind (ToM) deficits in neurodegeneration is still debated. There is contradicting evidence as to whether these cognitive processes are overlapping or distinct, which has clear clinical relevance for the evaluation of their associated clinical symptoms.
Aim: To investigate the relationship of EF and ToM deficits via a data-driven approach in a large sample of patients with behavioural variant frontotemporal dementia (bvFTD).
Methods: Data of 46 patients with bvFTD were employed in a hierarchical cluster analysis to determine the similarity of variance between different EF measures (verbal abstraction, verbal initiation, motor programming, sensitivity to interference, inhibitory control, visual abstraction, flexibility, working memory/attention) and ToM (faux pas).
Results: Overall results showed that EF measures were clustered separately from the ToM measure. A post hoc analysis revealed a more complex picture where selected ToM subcomponents (empathy; intention) showed a relationship to specific EF measures (verbal abstraction; working memory/attention), whereas the remaining EF and ToM subcomponents were separate.
Conclusions: Taken together, these findings suggest that EF and ToM are distinct components; however, ToM empathy and intention subcomponents might share some functions with specific EF processes. This has important implications for guiding diagnostic assessment of these deficits in clinical conditions.
Original languageEnglish
Pages (from-to)231-234
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume87
Issue number3
Early online date22 Oct 2015
DOIs
Publication statusPublished - Mar 2016

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