In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters

Shazad Mushtaq; Marina Warner; David M Livermore

doi:10.1093/jac/dkq306

In vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters

Shazad Mushtaq, Marina Warner, David M Livermore

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

NXL104 potentiates ceftazidime and ceftaroline against Enterobacteriaceae with extended-spectrum, AmpC, KPC and OXA β-lactamases. We examined whether similar potentiation was obtained against non-fermenters, which are less permeable than Enterobacteriaceae and have more potent efflux.

Original language	English
Pages (from-to)	2376-81
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	65
Issue number	11
DOIs	https://doi.org/10.1093/jac/dkq306
Publication status	Published - Nov 2010

Keywords

Acinetobacter baumannii
Anti-Bacterial Agents
Azabicyclo Compounds
Burkholderia cepacia complex
Ceftazidime
Drug Synergism
Humans
Microbial Sensitivity Tests
Pseudomonas aeruginosa
beta-Lactamases

Access to Document

10.1093/jac/dkq306

Cite this

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abstract = "NXL104 potentiates ceftazidime and ceftaroline against Enterobacteriaceae with extended-spectrum, AmpC, KPC and OXA β-lactamases. We examined whether similar potentiation was obtained against non-fermenters, which are less permeable than Enterobacteriaceae and have more potent efflux.",

keywords = "Acinetobacter baumannii, Anti-Bacterial Agents, Azabicyclo Compounds, Burkholderia cepacia complex, Ceftazidime, Drug Synergism, Humans, Microbial Sensitivity Tests, Pseudomonas aeruginosa, beta-Lactamases",

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KW - Burkholderia cepacia complex

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KW - Drug Synergism

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KW - Microbial Sensitivity Tests

KW - Pseudomonas aeruginosa

KW - beta-Lactamases

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