Abstract
Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter received at the United Kingdom's national reference laboratory Eravacycline MICs correlated closely with those of tigecycline but mostly were around two-fold lower; both molecule retained full activity against isolates with high-level tetracycline and minocycline resistance. MIC90s of eravacycline and tigecycline were raised ca. two-fold for carbapenem-resistant Enterobacteriaceae compared with carbapenem-susceptible controls, probably reflecting subsets of isolates with increased efflux.
| Original language | English |
|---|---|
| Pages (from-to) | 3840-3844 |
| Number of pages | 5 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 60 |
| Issue number | 6 |
| Early online date | 4 Apr 2016 |
| DOIs | |
| Publication status | Published - Jun 2016 |