In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii

David M. Livermore (Lead Author), Shazad Mushtaq, Marina Warner, Neil Woodford

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)
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Abstract

Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter received at the United Kingdom's national reference laboratory Eravacycline MICs correlated closely with those of tigecycline but mostly were around two-fold lower; both molecule retained full activity against isolates with high-level tetracycline and minocycline resistance. MIC90s of eravacycline and tigecycline were raised ca. two-fold for carbapenem-resistant Enterobacteriaceae compared with carbapenem-susceptible controls, probably reflecting subsets of isolates with increased efflux.
Original languageEnglish
Pages (from-to)3840-3844
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number6
Early online date4 Apr 2016
DOIs
Publication statusPublished - Jun 2016

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