In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci

David M Livermore, Marina Warner, Shazad Mushtaq, Sarah North, Neil Woodford

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RWJ-416457, a novel oxazolidinone, had modal MICs of 0.5 to 1 microg/ml for linezolid-susceptible staphylococci and enterococci, versus linezolid MICs for these organisms of 1 or 2 microg/ml. RWJ-416457 MICs for mutants with 23S rRNA mutations were 2 to 32 microg/ml, versus linezolid MICs of 8 to 64 microg/ml; actual values reflected the proportion of gene copies mutated.
Original languageEnglish
Pages (from-to)1112-4
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number3
Publication statusPublished - Mar 2007


  • Acetamides
  • Anti-Bacterial Agents
  • Drug Resistance, Bacterial
  • Enterococcus faecalis
  • Enterococcus faecium
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Mutation
  • Oxazolidinones
  • Polymorphism, Restriction Fragment Length
  • Reverse Transcriptase Polymerase Chain Reaction
  • Staphylococcus aureus

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