In vitro antibacterial activity of prenylated guanidine alkaloids from Pterogyne nitens and synthetic analogues

Aline Coqueiro, Luis Octávio Regasini, Paul Stapleton, Vanderlan da Silva Bolzani, Simon Gibbons

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The present investigation deals with the antibiotic activity of eight natural guanidine alkaloids and two synthetic analogues against a variety of clinically relevant methicillin-resistant Staphylococcus aureus strains. Galegine (1) and pterogynidine (2) were the most potent compounds, with a minimum inhibitory concentration of 4 mg/L, to all tested strains. The preliminary chemical features correlating to anti-MRSA activity showed that the size of the side chain and the substitution pattern in the guanidine core played a key role in the antibacterial activity of the imino group. Guanidine alkaloids 1 and 2 are promising molecular models for further synthetic derivatives and, thus, for medicinal chemistry studies.
Original languageEnglish
Pages (from-to)1972-1975
Number of pages4
JournalJournal of Natural Products
Volume77
Issue number8
Early online date4 Aug 2014
DOIs
Publication statusPublished - 22 Aug 2014

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