In vitro effect of DNA topoisomerase inhibitors on Candida albicans

Shing C. Kwok, Silke Schelenz, Xia Wang, Dietmar Steverding

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In this paper we report the results of the study of the in vitro effect of eight anticancer DNA topoisomerase inhibitors on the growth of Aspergillus fumigatus, A. niger, Candida glabrata and Cryptococcus neoformans. Only one compound, idarubicin, displayed promising antifungal activity against A. niger, C. glabrata and C. neoformans with MIC(50) values varying between 3.6 and 14.2 μM (1.8-7.1 μg/ml). Three other compounds, aclarubicin, doxorubicin and mitoxantrone, showed some antifungal activity against C. glabrata and C. neoformans with MIC(50) values in the mid micromolar range. The data of this study indicate that selected DNA topoisomerase inhibitors are a promising class of compounds for the development of new antifungal agents.
Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalMedical Mycology
Volume48
Issue number3
DOIs
Publication statusPublished - 2010

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