In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase

Eugenne Elliott, Adrian J. Brink, Johan van Greune, Zia Els, Neil Woodford, Jane Turton, Marina Warner, David M. Livermore

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120 Citations (Scopus)

Abstract

Four sequential extended-spectrum ß-lactamase—producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.
Original languageEnglish
Pages (from-to)E95-E98
JournalClinical Infectious Diseases
Volume42
Issue number11
DOIs
Publication statusPublished - 1 Jun 2006

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