In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase

Eugenne Elliott; Adrian J. Brink; Johan van Greune; Zia Els; Neil Woodford; Jane Turton; Marina Warner; David M. Livermore

doi:10.1086/503264

In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase

Eugenne Elliott, Adrian J. Brink, Johan van Greune, Zia Els, Neil Woodford, Jane Turton, Marina Warner, David M. Livermore

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Abstract

Four sequential extended-spectrum ß-lactamase—producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.

Original language	English
Pages (from-to)	E95-E98
Journal	Clinical Infectious Diseases
Volume	42
Issue number	11
DOIs	https://doi.org/10.1086/503264
Publication status	Published - 1 Jun 2006

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10.1086/503264

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title = "In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase",

abstract = "Four sequential extended-spectrum {\ss}-lactamase—producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.",

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AU - Els, Zia

AU - Woodford, Neil

AU - Turton, Jane

AU - Warner, Marina

AU - Livermore, David M.

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AB - Four sequential extended-spectrum ß-lactamase—producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.

U2 - 10.1086/503264

DO - 10.1086/503264

M3 - Article

SN - 1058-4838

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SP - E95-E98

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

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