Incipient parallel evolution of SARS-CoV-2 Deltacron variant in South Brazil

Fernando Hayashi Sant’Anna, Tiago Finger Andreis, Richard Steiner Salvato, Ana Paula Muterle Varela, Juliana Comerlato, Tatiana Schäffer Gregianini, Regina Bones Barcellos, Fernanda Marques de Souza Godinho, Paola Cristina Resende, Gabriel da Luz Wallau, Thaís Regina y Castro, Bruna Campestrini Casarin, Andressa de Almeida Vieira, Alexandre Vargas Schwarzbold, Priscila de Arruda Trindade, Gabriela Luchiari Tumioto Giannini, Luana Freese, Giovana Bristot, Carolina Serpa Brasil, Bruna de Oliveira RochaPaloma Bortolini Martins, Francine Hehn de Oliveira, Cock van Oosterhout, Eliana Wendland

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Abstract

With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5′ genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3′ genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel.

Original languageEnglish
Article number212
JournalVaccines
Volume11
Issue number2
Early online date18 Jan 2023
DOIs
Publication statusPublished - Feb 2023

Keywords

  • adaptive landscape
  • AYBA-RS
  • Brazil
  • COVID-19
  • Deltacron
  • gene flow
  • genetic introgression
  • recombinant
  • recombination
  • SARS-CoV-2 genomes
  • severe acute respiratory syndrome coronavirus 2

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