Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors

Chun Shing Kwok; Yoon Kong Loke

doi:10.1517/14740338.2012.657175

Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors

Chun Shing Kwok, Yoon Kong Loke

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

There is considerable debate surrounding the clinical relevance of an adverse interaction between clopidogrel and proton pump inhibitors (PPIs). Some studies have indicated that PPIs may attenuate the antiplatelet efficacy of clopidogrel, thus leading to increased risk of thrombotic cardiovascular events.

Original language	English
Pages (from-to)	275-84
Number of pages	10
Journal	Expert Opinion on Drug Safety
Volume	11
Issue number	2
DOIs	https://doi.org/10.1517/14740338.2012.657175
Publication status	Published - Mar 2012

Keywords

Animals
Blood Platelets
Drug Interactions
Evidence-Based Medicine
Gastrointestinal Hemorrhage
Humans
Platelet Aggregation Inhibitors
Proton Pump Inhibitors
Risk Assessment
Risk Factors
Ticlopidine

Access to Document

10.1517/14740338.2012.657175

Cite this

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title = "Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors",

abstract = "There is considerable debate surrounding the clinical relevance of an adverse interaction between clopidogrel and proton pump inhibitors (PPIs). Some studies have indicated that PPIs may attenuate the antiplatelet efficacy of clopidogrel, thus leading to increased risk of thrombotic cardiovascular events.",

keywords = "Animals, Blood Platelets, Drug Interactions, Evidence-Based Medicine, Gastrointestinal Hemorrhage, Humans, Platelet Aggregation Inhibitors, Proton Pump Inhibitors, Risk Assessment, Risk Factors, Ticlopidine",

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KW - Drug Interactions

KW - Evidence-Based Medicine

KW - Gastrointestinal Hemorrhage

KW - Humans

KW - Platelet Aggregation Inhibitors

KW - Proton Pump Inhibitors

KW - Risk Assessment

KW - Risk Factors

KW - Ticlopidine

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