Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion

Peter E. Langdon; Carolyn W. Harley; John H. McLean

doi:10.1016/S0165-3806(97)00090-4

Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion

Peter E. Langdon, Carolyn W. Harley, John H. McLean

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.

Original language	English
Pages (from-to)	291-293
Number of pages	3
Journal	Developmental Brain Research
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/S0165-3806(97)00090-4
Publication status	Published - 20 Sep 1997

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10.1016/S0165-3806(97)00090-4

Cite this

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abstract = "It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.",

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AB - It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.

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DO - 10.1016/S0165-3806(97)00090-4

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