Increased beta adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion

Peter E. Langdon, Carolyn W. Harley, John H. McLean

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45 Citations (Scopus)


It was hypothesized that 5-HT2 receptors in the olfactory bulb prime the bulbar response to a β adrenoceptor mediated unconditioned stimulus (UCS) during odor preference learning in 1-week-old rat pups. The ability of 4 mg/kg of isoproterenol+stroking and 6 mg/kg of isoproterenol+no stroking to induce normal odor preference learning in pups depleted of bulbar 5-HT in the present study supports the hypothesis. The inverted-U curve relation between UCS strength and learning also appears to occur within the bulb.
Original languageEnglish
Pages (from-to)291-293
Number of pages3
JournalDevelopmental Brain Research
Issue number2
Publication statusPublished - 20 Sep 1997

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