Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development

Jonathan M Harris, T William J Moorhead, Patrick Miller, Andrew M McIntosh, Heidi M Bonnici, David G C Owens, Eve C Johnstone, Stephen M Lawrie

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107 Citations (Scopus)


In our cohort considered at high risk (HR) of developing schizophrenia, we previously found a significant difference in extent of right prefrontal cortical folding between those who subsequently developed schizophrenia and a matched group who remained well. This study aimed to determine if this preexisting difference distinguished 17 individuals who developed schizophrenia from the 128 HR individuals in the cohort who remained well and to explore possible underlying differences in cortical composition.
Original languageEnglish
Pages (from-to)722-9
Number of pages8
JournalBiological Psychiatry
Issue number7
Publication statusPublished - 1 Oct 2007


  • Adolescent
  • Adult
  • Cohort Studies
  • Female
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted
  • Logistic Models
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Prefrontal Cortex
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Risk
  • Schizophrenia

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