TY - JOUR
T1 - Increasing antituberculosis drug resistance in the United Kingdom: analysis of national surveillance data
AU - Kruijshaar, Michelle E.
AU - Watson, John M.
AU - Drobniewski, Francis
AU - Anderson, Charlotte
AU - Brown, Timothy J.
AU - Magee, John G.
AU - Smith, E. Grace
AU - Story, Alistair
AU - Abubakar, Ibrahim
PY - 2008/5/31
Y1 - 2008/5/31
N2 - Objective To identify recent trends in, and factors associated with, resistance to antituberculosis drugs in England, Wales, and Northern Ireland.
Design Cohort of tuberculosis cases reported to the enhanced tuberculosis surveillance system matched to data on drug susceptibility and national strain typing data.
Setting England, Wales, and Northern Ireland 1998-2005.
Main outcome measures Unadjusted and adjusted odds ratios for drug resistance and associated factors. Proportion of multidrug resistant tuberculosis cases clustered.
Results 28?620 culture confirmed cases were available for analysis. The proportion of cases resistant to isoniazid increased from 5% to 7%. Rifampicin resistance increased from 1.0% to 1.2% and multidrug resistance from 0.8% to 0.9%. Ethambutol and pyrazinamide resistance remained stable at around 0.4% and 0.6%, respectively. Regression analyses showed a significant increase in isoniazid resistance outside London (odds ratio 1.04, 95% confidence interval 1.01 to 1.07, a year, associated with changes in age (0.98, 0.98 to 0.99, a year), place of birth (1.49, 1.16 to 1.92), and ethnicity (P
AB - Objective To identify recent trends in, and factors associated with, resistance to antituberculosis drugs in England, Wales, and Northern Ireland.
Design Cohort of tuberculosis cases reported to the enhanced tuberculosis surveillance system matched to data on drug susceptibility and national strain typing data.
Setting England, Wales, and Northern Ireland 1998-2005.
Main outcome measures Unadjusted and adjusted odds ratios for drug resistance and associated factors. Proportion of multidrug resistant tuberculosis cases clustered.
Results 28?620 culture confirmed cases were available for analysis. The proportion of cases resistant to isoniazid increased from 5% to 7%. Rifampicin resistance increased from 1.0% to 1.2% and multidrug resistance from 0.8% to 0.9%. Ethambutol and pyrazinamide resistance remained stable at around 0.4% and 0.6%, respectively. Regression analyses showed a significant increase in isoniazid resistance outside London (odds ratio 1.04, 95% confidence interval 1.01 to 1.07, a year, associated with changes in age (0.98, 0.98 to 0.99, a year), place of birth (1.49, 1.16 to 1.92), and ethnicity (P
U2 - 10.1136/bmj.39546.573067.25
DO - 10.1136/bmj.39546.573067.25
M3 - Article
VL - 336
SP - 1231
EP - 1234
JO - BMJ-British Medical Journal
JF - BMJ-British Medical Journal
SN - 1759-2151
IS - 7655
ER -
