Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

Natalie J Prescott; Katherine M Dominy; Michiaki Kubo; Cathryn M Lewis; Sheila A Fisher; Richard Redon; Ni Huang; Barbara E Stranger; Katarzyna Blaszczyk; Barry Hudspith; Gareth Parkes; Naoya Hosono; Keiko Yamazaki; Clive M Onnie; Alastair Forbes; Emmanouil T Dermitzakis; Yusuke Nakamura; John C Mansfield; Jeremy Sanderson; Matthew E Hurles; Roland G Roberts; Christopher G Mathew

doi:10.1093/hmg/ddq041

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

Natalie J Prescott, Katherine M Dominy, Michiaki Kubo, Cathryn M Lewis, Sheila A Fisher, Richard Redon, Ni Huang, Barbara E Stranger, Katarzyna Blaszczyk, Barry Hudspith, Gareth Parkes, Naoya Hosono, Keiko Yamazaki, Clive M Onnie, Alastair Forbes, Emmanouil T Dermitzakis, Yusuke Nakamura, John C Mansfield, Jeremy Sanderson, Matthew E HurlesRoland G Roberts, Christopher G Mathew

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P

Original language	English
Pages (from-to)	1828-1839
Number of pages	12
Journal	Human Molecular Genetics
Volume	19
Issue number	9
DOIs	https://doi.org/10.1093/hmg/ddq041
Publication status	Published - 1 May 2010

Keywords

Asian Continental Ancestry Group
Base Sequence
Crohn Disease
DNA Copy Number Variations
DNA Primers
European Continental Ancestry Group
GTP-Binding Proteins
Genetic Predisposition to Disease
Genetic Variation
Genotype
Great Britain
Haplotypes
Humans
INDEL Mutation
Logistic Models
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Promoter Regions, Genetic
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA

Access to Document

10.1093/hmg/ddq041

Cite this

Prescott, N. J., Dominy, K. M., Kubo, M., Lewis, C. M., Fisher, S. A., Redon, R., Huang, N., Stranger, B. E., Blaszczyk, K., Hudspith, B., Parkes, G., Hosono, N., Yamazaki, K., Onnie, C. M., Forbes, A., Dermitzakis, E. T., Nakamura, Y., Mansfield, J. C., Sanderson, J., ... Mathew, C. G. (2010). Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Human Molecular Genetics, 19(9), 1828-1839. https://doi.org/10.1093/hmg/ddq041

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title = "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease",

abstract = "DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P ",

keywords = "Asian Continental Ancestry Group, Base Sequence, Crohn Disease, DNA Copy Number Variations, DNA Primers, European Continental Ancestry Group, GTP-Binding Proteins, Genetic Predisposition to Disease, Genetic Variation, Genotype, Great Britain, Haplotypes, Humans, INDEL Mutation, Logistic Models, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Promoter Regions, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA",

author = "Prescott, {Natalie J} and Dominy, {Katherine M} and Michiaki Kubo and Lewis, {Cathryn M} and Fisher, {Sheila A} and Richard Redon and Ni Huang and Stranger, {Barbara E} and Katarzyna Blaszczyk and Barry Hudspith and Gareth Parkes and Naoya Hosono and Keiko Yamazaki and Onnie, {Clive M} and Alastair Forbes and Dermitzakis, {Emmanouil T} and Yusuke Nakamura and Mansfield, {John C} and Jeremy Sanderson and Hurles, {Matthew E} and Roberts, {Roland G} and Mathew, {Christopher G}",

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month = may,

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doi = "10.1093/hmg/ddq041",

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Prescott, NJ, Dominy, KM, Kubo, M, Lewis, CM, Fisher, SA, Redon, R, Huang, N, Stranger, BE, Blaszczyk, K, Hudspith, B, Parkes, G, Hosono, N, Yamazaki, K, Onnie, CM, Forbes, A, Dermitzakis, ET, Nakamura, Y, Mansfield, JC, Sanderson, J, Hurles, ME, Roberts, RG & Mathew, CG 2010, 'Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease', Human Molecular Genetics, vol. 19, no. 9, pp. 1828-1839. https://doi.org/10.1093/hmg/ddq041

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T1 - Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

AU - Prescott, Natalie J

AU - Dominy, Katherine M

AU - Kubo, Michiaki

AU - Lewis, Cathryn M

AU - Fisher, Sheila A

AU - Redon, Richard

AU - Huang, Ni

AU - Stranger, Barbara E

AU - Blaszczyk, Katarzyna

AU - Hudspith, Barry

AU - Parkes, Gareth

AU - Hosono, Naoya

AU - Yamazaki, Keiko

AU - Onnie, Clive M

AU - Forbes, Alastair

AU - Dermitzakis, Emmanouil T

AU - Nakamura, Yusuke

AU - Mansfield, John C

AU - Sanderson, Jeremy

AU - Hurles, Matthew E

AU - Roberts, Roland G

AU - Mathew, Christopher G

PY - 2010/5/1

Y1 - 2010/5/1

N2 - DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P

AB - DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P

KW - Asian Continental Ancestry Group

KW - Base Sequence

KW - Crohn Disease

KW - DNA Copy Number Variations

KW - DNA Primers

KW - European Continental Ancestry Group

KW - GTP-Binding Proteins

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genotype

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - INDEL Mutation

KW - Logistic Models

KW - Molecular Sequence Data

KW - Oligonucleotide Array Sequence Analysis

KW - Promoter Regions, Genetic

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sequence Analysis, DNA

U2 - 10.1093/hmg/ddq041

DO - 10.1093/hmg/ddq041

M3 - Article

C2 - 20106866

VL - 19

SP - 1828

EP - 1839

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 9

ER -