Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

Anastasia Georgiadi, Laeticia Lichtenstein, Tatjana Degenhardt, Mark V Boekschoten, Marc van Bilsen, Beatrice Desvergne, Michael Müller, Sander Kersten

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart.
Original languageEnglish
Pages (from-to)1712-1721
Number of pages10
JournalCirculation Research
Volume106
Issue number11
DOIs
Publication statusPublished - 11 Jun 2010

Keywords

  • Angiopoietins
  • Animals
  • Animals, Newborn
  • Cardiomyopathies
  • Cells, Cultured
  • Cytoprotection
  • Dietary Fats
  • Fatty Acids, Unsaturated
  • Feedback, Physiological
  • Linoleic Acid
  • Lipid Peroxidation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardium
  • Oleic Acid
  • Oxidative Stress
  • PPAR delta
  • PPAR-beta
  • RNA Interference
  • Time Factors
  • Up-Regulation
  • alpha-Linolenic Acid

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