Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

Anastasia Georgiadi; Laeticia Lichtenstein; Tatjana Degenhardt; Mark V Boekschoten; Marc van Bilsen; Beatrice Desvergne; Michael Müller; Sander Kersten

doi:10.1161/CIRCRESAHA.110.217380

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

Anastasia Georgiadi, Laeticia Lichtenstein, Tatjana Degenhardt, Mark V Boekschoten, Marc van Bilsen, Beatrice Desvergne, Michael Müller, Sander Kersten

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart.

Original language	English
Pages (from-to)	1712-1721
Number of pages	10
Journal	Circulation Research
Volume	106
Issue number	11
DOIs	https://doi.org/10.1161/CIRCRESAHA.110.217380
Publication status	Published - 11 Jun 2010

Keywords

Angiopoietins
Animals
Animals, Newborn
Cardiomyopathies
Cells, Cultured
Cytoprotection
Dietary Fats
Fatty Acids, Unsaturated
Feedback, Physiological
Linoleic Acid
Lipid Peroxidation
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardium
Oleic Acid
Oxidative Stress
PPAR delta
PPAR-beta
RNA Interference
Time Factors
Up-Regulation
alpha-Linolenic Acid

Access to Document

10.1161/CIRCRESAHA.110.217380

Cite this

Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Müller, M., & Kersten, S. (2010). Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. Circulation Research, 106(11), 1712-1721. https://doi.org/10.1161/CIRCRESAHA.110.217380

@article{ea83255f4084427e86d2673e4966e49f,

title = "Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress",

abstract = "Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart.",

keywords = "Angiopoietins, Animals, Animals, Newborn, Cardiomyopathies, Cells, Cultured, Cytoprotection, Dietary Fats, Fatty Acids, Unsaturated, Feedback, Physiological, Linoleic Acid, Lipid Peroxidation, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardium, Oleic Acid, Oxidative Stress, PPAR delta, PPAR-beta, RNA Interference, Time Factors, Up-Regulation, alpha-Linolenic Acid",

author = "Anastasia Georgiadi and Laeticia Lichtenstein and Tatjana Degenhardt and Boekschoten, {Mark V} and {van Bilsen}, Marc and Beatrice Desvergne and Michael M{\"u}ller and Sander Kersten",

year = "2010",

month = jun,

day = "11",

doi = "10.1161/CIRCRESAHA.110.217380",

language = "English",

volume = "106",

pages = "1712--1721",

journal = "Circulation Research",

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publisher = "Lippincott, Williams and Wilkins",

number = "11",

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Georgiadi, A, Lichtenstein, L, Degenhardt, T, Boekschoten, MV, van Bilsen, M, Desvergne, B, Müller, M & Kersten, S 2010, 'Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress', Circulation Research, vol. 106, no. 11, pp. 1712-1721. https://doi.org/10.1161/CIRCRESAHA.110.217380

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. / Georgiadi, Anastasia; Lichtenstein, Laeticia; Degenhardt, Tatjana et al.
In: Circulation Research, Vol. 106, No. 11, 11.06.2010, p. 1712-1721.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

AU - Georgiadi, Anastasia

AU - Lichtenstein, Laeticia

AU - Degenhardt, Tatjana

AU - Boekschoten, Mark V

AU - van Bilsen, Marc

AU - Desvergne, Beatrice

AU - Müller, Michael

AU - Kersten, Sander

PY - 2010/6/11

Y1 - 2010/6/11

N2 - Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart.

AB - Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart.

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KW - Animals

KW - Animals, Newborn

KW - Cardiomyopathies

KW - Cells, Cultured

KW - Cytoprotection

KW - Dietary Fats

KW - Fatty Acids, Unsaturated

KW - Feedback, Physiological

KW - Linoleic Acid

KW - Lipid Peroxidation

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Myocardium

KW - Oleic Acid

KW - Oxidative Stress

KW - PPAR delta

KW - PPAR-beta

KW - RNA Interference

KW - Time Factors

KW - Up-Regulation

KW - alpha-Linolenic Acid

U2 - 10.1161/CIRCRESAHA.110.217380

DO - 10.1161/CIRCRESAHA.110.217380

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C2 - 20378851

SN - 0009-7330

VL - 106

SP - 1712

EP - 1721

JO - Circulation Research

JF - Circulation Research

IS - 11

ER -