Inflammation and depression: A public health perspective

Alexander L. Chu, Matthew Hickman, Nicholas Steel, Peter B. Jones, George Davey Smith, Golam M. Khandaker

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)
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The multifaceted role of low-grade systemic inflammation in depression and physical illnesses like cardiovascular disease highlights complex interactions between the body, brain and mind. While current research on inflammation and depression has largely focused on exploring possible disease mechanisms and therapeutic potential, we seek to broaden the current discussion by introducing a public health perspective. In this Viewpoint, we propose that inflammation and its contributing sources could represent important targets for public health strategies aimed at improving both mental and physical health. We discuss potential universal, selective and indicated primary prevention strategies for inflammation-related depression. We consider potential approaches to secondary prevention, including scope for anti-inflammatory treatment and CRP testing for guiding treatment allocation and prognosis. Preventive strategies discussed here could also be relevant for other inflammation-mediated mental health conditions.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalBrain, Behavior, and Immunity
Early online date18 Apr 2021
Publication statusPublished - Jul 2021


  • Depression
  • Immunopsychiatry
  • Inflammation
  • Mental Health
  • Prevention
  • Public Health

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