Inflammation and frailty measures in older people

Ruth E Hubbard, M Sinead O'Mahony, George M Savva, Brian L Calver, Ken W Woodhouse

Research output: Contribution to journalArticlepeer-review

299 Citations (Scopus)


Inflammation in patients defined as frail by Fried's phenotypic definition may be related to sarcopenia. This study aimed to investigate inflammation in older patients across different frailty criteria. Frailty status was determined in 110 patients aged over 75 years (mean 83.9 years) according to function (dependent, intermediate, independent); Fried (three or more items of exhaustion, weight loss, slow walking speed, low handgrip strength, low physical activity) and Frailty Index (a measure of accumulated deficits). With increasing patient frailty as defined by function and by Fried phenotype, tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) increased significantly. Albumin was lowest in the frailest subjects by each definition. The greatest differences were seen between intermediate and dependent groups and between the pre-frail and frail. Adjustment for multiple covariates (age, sex, BMI category, smoking status, number of co-morbidities and number of prescribed medications) did not account for any of the observed differences in levels of inflammatory markers. The Frailty Index correlated significantly with log-transformed CRP (r= 0.221, P
Original languageEnglish
Pages (from-to)3103-3109
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Issue number9B
Publication statusPublished - Sep 2009


  • Aged
  • Aged, 80 and over
  • Albumins
  • Body Mass Index
  • C-Reactive Protein
  • Comorbidity
  • Female
  • Frail Elderly
  • Humans
  • Inflammation
  • Interleukin-6
  • Male
  • Phenotype
  • Smoking
  • Tumor Necrosis Factor-alpha

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