Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study

N L Henry, D Pchejetski, R A'Hern, A T Nguyen, P Charles, J Waxman, L Li, A M Storniolo, D F Hayes, D A Flockhart, V Stearns, J Stebbing

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32 Citations (Scopus)

Abstract

The aromatase inhibitor (AI)-associated musculoskeletal syndrome (AIMSS) occurs in approximately 50% of AI-treated patients. Inflammatory mediators are associated with oestrogen signalling and may change with oestrogen depletion. We hypothesised that AIMSS may be associated with changes in circulating inflammatory markers.
Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalBritish Journal of Cancer
Volume103
Issue number3
DOIs
Publication statusPublished - 27 Jul 2010

Keywords

  • Aged
  • Androstadienes
  • Antineoplastic Agents
  • Aromatase Inhibitors
  • Breast Neoplasms
  • Bridged Compounds
  • Case-Control Studies
  • Cytokines
  • Estrogens
  • Female
  • Humans
  • Inflammation
  • Middle Aged
  • Musculoskeletal Diseases
  • Postmenopause
  • Syndrome
  • Tamoxifen
  • Taxoids

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