Influence of the APOC3 −2854T>G polymorphism on plasma lipid levels: effect of age and gender

Anne Marie Minihane; Yvonne E. Finnegan; Philippa Talmud; Elizabeth C. Leigh-Firbank; Christine M. Williams

doi:10.1016/S1388-1981(02)00264-0

Influence of the APOC3 −2854T>G polymorphism on plasma lipid levels: effect of age and gender

Anne Marie Minihane
, Yvonne E. Finnegan
, Philippa Talmud
, Elizabeth C. Leigh-Firbank
, Christine M. Williams

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

The APOC3 −2854T>G polymorphism lies in the APOC3–A4 intergenic region. In a group of healthy adults, this polymorphism was associated with circulating triglycerides, with 55% lower fasting levels in the homozygous wild-type (TT) compared to the homozygous rare allele (GG) genotype. Age and gender had a significant impact on genotype–triglyceride interactions.

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Volume	1583
Issue number	3
DOIs	https://doi.org/10.1016/S1388-1981(02)00264-0
Publication status	Published - 8 Aug 2002

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10.1016/S1388-1981(02)00264-0

Cite this

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title = "Influence of the APOC3 −2854T>G polymorphism on plasma lipid levels: effect of age and gender",

abstract = "The APOC3 −2854T>G polymorphism lies in the APOC3{\textendash}A4 intergenic region. In a group of healthy adults, this polymorphism was associated with circulating triglycerides, with 55\% lower fasting levels in the homozygous wild-type (TT) compared to the homozygous rare allele (GG) genotype. Age and gender had a significant impact on genotype{\textendash}triglyceride interactions.",

author = "Minihane, \{Anne Marie\} and Finnegan, \{Yvonne E.\} and Philippa Talmud and Leigh-Firbank, \{Elizabeth C.\} and Williams, \{Christine M.\}",

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pages = "311--314",

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AU - Minihane, Anne Marie

AU - Finnegan, Yvonne E.

AU - Talmud, Philippa

AU - Leigh-Firbank, Elizabeth C.

AU - Williams, Christine M.

PY - 2002/8/8

Y1 - 2002/8/8

N2 - The APOC3 −2854T>G polymorphism lies in the APOC3–A4 intergenic region. In a group of healthy adults, this polymorphism was associated with circulating triglycerides, with 55% lower fasting levels in the homozygous wild-type (TT) compared to the homozygous rare allele (GG) genotype. Age and gender had a significant impact on genotype–triglyceride interactions.

AB - The APOC3 −2854T>G polymorphism lies in the APOC3–A4 intergenic region. In a group of healthy adults, this polymorphism was associated with circulating triglycerides, with 55% lower fasting levels in the homozygous wild-type (TT) compared to the homozygous rare allele (GG) genotype. Age and gender had a significant impact on genotype–triglyceride interactions.

U2 - 10.1016/S1388-1981(02)00264-0

DO - 10.1016/S1388-1981(02)00264-0

M3 - Article

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EP - 314

JO - Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

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