Inhibition of electrical activity in mouse pancreatic beta- cells by the Atp/Adp translocase inhibitor, Bongkrekic Acid

B. Kiranadi, J. A. Bangham, P. A. Smith

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic β-cell through the simulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing β-cel function.
Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalFEBS Letters
Issue number1
Publication statusPublished - 20 May 1991

Cite this