Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro

G. P. Riley; M. Cox; R. L. Harrall; S. Clements; B. L. Hazleman

doi:10.1054/jhsb.2001.0560

Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro

G. P. Riley, M. Cox, R. L. Harrall, S. Clements, B. L. Hazleman

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

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Abstract

The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of 3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of 35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery.

Original language	English
Pages (from-to)	224-228
Number of pages	5
Journal	The Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand
Volume	26
Issue number	3
DOIs	https://doi.org/10.1054/jhsb.2001.0560
Publication status	Published - Jun 2001

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Cite this

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title = "Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro",

abstract = "The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of 3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of 35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery.",

author = "Riley, {G. P.} and M. Cox and Harrall, {R. L.} and S. Clements and Hazleman, {B. L.}",

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pages = "224--228",

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Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro. / Riley, G. P.; Cox, M.; Harrall, R. L. et al.

In: The Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand, Vol. 26, No. 3, 06.2001, p. 224-228.

Research output: Contribution to journal › Article › peer-review

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