Integrated view of Vibrio cholerae in the Americas

Daryl Domman; Marie-laure Quilici; Matthew J. Dorman; Elisabeth Njamkepo; Ankur Mutreja; Alison E. Mather; Gabriella Delgado; Rosario Morales-Espinosa; Patrick A. D. Grimont; Marcial Leonardo Lizárraga-Partida; Christiane Bouchier; David M. Aanensen; Pablo Kuri-Morales; Cheryl L. Tarr; Gordon Dougan; Julian Parkhill; Josefina Campos; Alejandro Cravioto; François-Xavier Weill; Nicholas R. Thomson

doi:10.1126/science.aao2136

Integrated view of Vibrio cholerae in the Americas

Daryl Domman, Marie-laure Quilici, Matthew J. Dorman, Elisabeth Njamkepo, Ankur Mutreja, Alison E. Mather, Gabriella Delgado, Rosario Morales-Espinosa, Patrick A. D. Grimont, Marcial Leonardo Lizárraga-Partida, Christiane Bouchier, David M. Aanensen, Pablo Kuri-Morales, Cheryl L. Tarr, Gordon Dougan, Julian Parkhill, Josefina Campos, Alejandro Cravioto, François-Xavier Weill, Nicholas R. Thomson

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.

Original language	English
Pages (from-to)	789-793
Number of pages	5
Journal	Science
Volume	358
Issue number	6364
DOIs	https://doi.org/10.1126/science.aao2136
Publication status	Published - 10 Nov 2017

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10.1126/science.aao2136

Cite this

Domman, D., Quilici, M., Dorman, M. J., Njamkepo, E., Mutreja, A., Mather, A. E., Delgado, G., Morales-Espinosa, R., Grimont, P. A. D., Lizárraga-Partida, M. L., Bouchier, C., Aanensen, D. M., Kuri-Morales, P., Tarr, C. L., Dougan, G., Parkhill, J., Campos, J., Cravioto, A., Weill, F-X., & Thomson, N. R. (2017). Integrated view of Vibrio cholerae in the Americas. Science, 358(6364), 789-793. https://doi.org/10.1126/science.aao2136

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title = "Integrated view of Vibrio cholerae in the Americas",

abstract = "Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.",

author = "Daryl Domman and Marie-laure Quilici and Dorman, {Matthew J.} and Elisabeth Njamkepo and Ankur Mutreja and Mather, {Alison E.} and Gabriella Delgado and Rosario Morales-Espinosa and Grimont, {Patrick A. D.} and Liz{\'a}rraga-Partida, {Marcial Leonardo} and Christiane Bouchier and Aanensen, {David M.} and Pablo Kuri-Morales and Tarr, {Cheryl L.} and Gordon Dougan and Julian Parkhill and Josefina Campos and Alejandro Cravioto and Fran{\c c}ois-Xavier Weill and Thomson, {Nicholas R.}",

year = "2017",

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doi = "10.1126/science.aao2136",

language = "English",

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Domman, D, Quilici, M, Dorman, MJ, Njamkepo, E, Mutreja, A, Mather, AE, Delgado, G, Morales-Espinosa, R, Grimont, PAD, Lizárraga-Partida, ML, Bouchier, C, Aanensen, DM, Kuri-Morales, P, Tarr, CL, Dougan, G, Parkhill, J, Campos, J, Cravioto, A, Weill, F-X & Thomson, NR 2017, 'Integrated view of Vibrio cholerae in the Americas', Science, vol. 358, no. 6364, pp. 789-793. https://doi.org/10.1126/science.aao2136

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AU - Domman, Daryl

AU - Quilici, Marie-laure

AU - Dorman, Matthew J.

AU - Njamkepo, Elisabeth

AU - Mutreja, Ankur

AU - Mather, Alison E.

AU - Delgado, Gabriella

AU - Morales-Espinosa, Rosario

AU - Grimont, Patrick A. D.

AU - Lizárraga-Partida, Marcial Leonardo

AU - Bouchier, Christiane

AU - Aanensen, David M.

AU - Kuri-Morales, Pablo

AU - Tarr, Cheryl L.

AU - Dougan, Gordon

AU - Parkhill, Julian

AU - Campos, Josefina

AU - Cravioto, Alejandro

AU - Weill, François-Xavier

AU - Thomson, Nicholas R.

PY - 2017/11/10

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AB - Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.

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