Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer

Sameer Jhavar, Daniel Brewer, Sandra Edwards, Zsofia Kote-Jarai, Gerhardt Attard, Jeremy Clark, Penny Flohr, Timothy Christmas, Alan Thompson, Matthew Parker, Christopher Shepherd, Ulf-Hakan Stenman, Tania Marchbank, Raymond J Playford, Christopher Woodhouse, Christopher Ogden, Cyril Fisher, Gyula Kovacs, Cathy Corbishley, Charles JamesonAndy Norman, Johann De-Bono, Anders Bjartell, Rosalind Eeles, Colin S Cooper

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

To integrate the mapping of ERG alterations with the collection of expression microarray (EMA) data, as previous EMA analyses have failed to consider the genetic heterogeneity and complex patterns of ERG alteration frequently found in cancerous prostates.
Original languageEnglish
Pages (from-to)1256-69
Number of pages14
JournalBJU International
Volume103
Issue number9
DOIs
Publication statusPublished - May 2009

Keywords

  • Carrier Proteins
  • Chromosome Mapping
  • Gene Expression Profiling
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Male
  • Prostatic Neoplasms
  • Trans-Activators

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