Inter-seasonal diversity of norovirus genotypes: Emergence and selection of virus variants

C. I. Gallimore, M. Iturriza-Gomara, J. Xerry, J. Adigwe, J. J. Gray

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This study describes a method used to determine the diversity of NoVs co-circulating in the community that consisted of the analysis of a limited number of strains collected from outbreaks occurring at different times of the NoV season. The diversity of twenty NoV strains collected from outbreaks occurring at the beginning of each NoV season (September) was compared to the diversity found in the middle (December) and at the end of the season (March). The method was validated through the characterisation of greater numbers of strains at times when novel genotypes or variants were detected. A total of 864 strains from outbreaks of gastroenteritis from the 2003/04, 2004/05 and 2005/06 seasons were genotyped, with the majority of outbreaks occurring in the UK.
Original languageEnglish
Pages (from-to)1295-1303
Number of pages9
JournalArchives of Virology
Issue number7
Publication statusPublished - 2007

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