Interaction of heparin with Ca2+: A model study with a synthetic heparin-like hexasaccharide

Jesús Angulo, José-luis De Paz, Pedro M. Nieto, Manuel Martín-lomas

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The binding of Ca2+ to synthetic hexasaccharide 1, containing the structural motifs of the regular region of heparin, has been investigated using NMR spectroscopy and molecular modeling. The NMR data of the calcium salt of 1 indicate the existence of specific Ca2+ binding, and molecular modeling results predict three different types of binding sites with different negative potential and preorganized geometry. The presence of Ca2+ does not seem to affect the overall helical structure of hexasaccharide 1, although it seems to have a marked influence on the flexibility of the oligosaccharide backbone.
Original languageEnglish
Pages (from-to)289-299
Number of pages11
JournalIsrael Journal of Chemistry
Issue number3-4
Publication statusPublished - 1 May 2001

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