Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte; Ainara García; Marion Décossas; Wafa' T. Al-Jamal; Shouping Li; Kostas Kostarelos; Sylviane Muller; Maurizio Prato; Hélène Dumortier; Alberto Bianco

doi:10.1002/adma.v20:12

Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte, Ainara García, Marion Décossas, Wafa' T. Al-Jamal, Shouping Li, Kostas Kostarelos, Sylviane Muller, Maurizio Prato, Hélène Dumortier, Alberto Bianco

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

Original language	English
Pages (from-to)	2421-2426
Number of pages	6
Journal	Advanced Materials
Volume	20
Issue number	12
DOIs	https://doi.org/10.1002/adma.v20:12
Publication status	Published - 18 Jun 2008

Access to Document

10.1002/adma.v20:12

Cite this

@article{8701e4efb392454d97e538d79d98544d,

title = "Interfacing functionalized carbon nanohorns with primary phagocytic cells",

abstract = "Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.",

author = "St{\'e}phanie Lacotte and Ainara Garc{\'i}a and Marion D{\'e}cossas and Al-Jamal, {Wafa' T.} and Shouping Li and Kostas Kostarelos and Sylviane Muller and Maurizio Prato and H{\'e}l{\`e}ne Dumortier and Alberto Bianco",

year = "2008",

month = jun,

day = "18",

doi = "10.1002/adma.v20:12",

language = "English",

volume = "20",

pages = "2421--2426",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley",

number = "12",

}

TY - JOUR

T1 - Interfacing functionalized carbon nanohorns with primary phagocytic cells

AU - Lacotte, Stéphanie

AU - García, Ainara

AU - Décossas, Marion

AU - Al-Jamal, Wafa' T.

AU - Li, Shouping

AU - Kostarelos, Kostas

AU - Muller, Sylviane

AU - Prato, Maurizio

AU - Dumortier, Hélène

AU - Bianco, Alberto

PY - 2008/6/18

Y1 - 2008/6/18

N2 - Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

AB - Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

U2 - 10.1002/adma.v20:12

DO - 10.1002/adma.v20:12

M3 - Article

SN - 0935-9648

VL - 20

SP - 2421

EP - 2426

JO - Advanced Materials

JF - Advanced Materials

IS - 12

ER -