Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte, Ainara García, Marion Décossas, Wafa' T. Al-Jamal, Shouping Li, Kostas Kostarelos, Sylviane Muller, Maurizio Prato, Hélène Dumortier, Alberto Bianco

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.
Original languageEnglish
Pages (from-to)2421-2426
Number of pages6
JournalAdvanced Materials
Volume20
Issue number12
DOIs
Publication statusPublished - 18 Jun 2008

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