Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte; Ainara García; Marion Décossas; Wafa' T. Al-Jamal; Shouping Li; Kostas Kostarelos; Sylviane Muller; Maurizio Prato; Hélène Dumortier; Alberto Bianco

doi:10.1002/adma.v20:12

Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte
, Ainara García
, Marion Décossas
, Wafa' T. Al-Jamal
, Shouping Li
, Kostas Kostarelos
, Sylviane Muller
, Maurizio Prato
, Hélène Dumortier
, Alberto Bianco

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

Original language	English
Pages (from-to)	2421-2426
Number of pages	6
Journal	Advanced Materials
Volume	20
Issue number	12
DOIs	https://doi.org/10.1002/adma.v20:12
Publication status	Published - 18 Jun 2008

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10.1002/adma.v20:12

Cite this

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title = "Interfacing functionalized carbon nanohorns with primary phagocytic cells",

abstract = "Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.",

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AU - Lacotte, Stéphanie

AU - García, Ainara

AU - Décossas, Marion

AU - Al-Jamal, Wafa' T.

AU - Li, Shouping

AU - Kostarelos, Kostas

AU - Muller, Sylviane

AU - Prato, Maurizio

AU - Dumortier, Hélène

AU - Bianco, Alberto

PY - 2008/6/18

Y1 - 2008/6/18

N2 - Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

AB - Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

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DO - 10.1002/adma.v20:12

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