TY - JOUR
T1 - Interindividual variability in biomarkers of cardiometabolic health after consumption of major plant-food bioactive compounds and the determinants involved
AU - Milenkovic, Dragan
AU - Morand, Christine
AU - Cassidy, Aedin
AU - Konic-Ristic, Aleksandra
AU - Tomás-Barberán, Francisco
AU - Ordovas, José M
AU - Kroon, Paul
AU - De Caterina, Raffaele
AU - Rodriguez-Mateos, Ana
N1 - © 2017 American Society for Nutrition.
PY - 2017/7
Y1 - 2017/7
N2 - Cardiometabolic disease, comprising cardiovascular diseases, type 2 diabetes, and their associated risk factors including metabolic syndrome and obesity, is the leading cause of death worldwide. Plant foods are rich sources of different groups of bioactive compounds, which might not be essential throughout life but promote health and well-being by reducing the risk of age-related chronic diseases. However, heterogeneity in the responsiveness to bioactive compounds can obscure associations between their intakes and health outcomes, resulting in the hiding of health benefits for specific population groups and thereby limiting our knowledge of the exact role of the different bioactive compounds for health. The heterogeneity in response suggests that some individuals may benefit more than others from the health effects of these bioactive compounds. However, to date, this interindividual variation after habitual intake of plant bioactive compounds has been little explored. The aim of this review is to provide an overview of the existing research that has revealed interindividual variability in the responsiveness to plant-food bioactive compound consumption regarding cardiometabolic outcomes, focusing on polyphenols, caffeine and plant sterols, and the identified potential determinants involved.
AB - Cardiometabolic disease, comprising cardiovascular diseases, type 2 diabetes, and their associated risk factors including metabolic syndrome and obesity, is the leading cause of death worldwide. Plant foods are rich sources of different groups of bioactive compounds, which might not be essential throughout life but promote health and well-being by reducing the risk of age-related chronic diseases. However, heterogeneity in the responsiveness to bioactive compounds can obscure associations between their intakes and health outcomes, resulting in the hiding of health benefits for specific population groups and thereby limiting our knowledge of the exact role of the different bioactive compounds for health. The heterogeneity in response suggests that some individuals may benefit more than others from the health effects of these bioactive compounds. However, to date, this interindividual variation after habitual intake of plant bioactive compounds has been little explored. The aim of this review is to provide an overview of the existing research that has revealed interindividual variability in the responsiveness to plant-food bioactive compound consumption regarding cardiometabolic outcomes, focusing on polyphenols, caffeine and plant sterols, and the identified potential determinants involved.
KW - plant-food bioactives
KW - interindividual variability
KW - cardiometabolic health
KW - determinants of interindividual variability
KW - biological responsiveness
U2 - 10.3945/an.116.013623
DO - 10.3945/an.116.013623
M3 - Article
C2 - 28710143
VL - 8
SP - 558
EP - 570
JO - Advances in Nutrition
JF - Advances in Nutrition
SN - 2161-8313
IS - 4
ER -