Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

J F Colombel; P Rutgeerts; H Malchow; M Jacyna; O H Nielsen; J Rask-Madsen; S Van Deventer; A Ferguson; P Desreumaux; A Forbes; K Geboes; L Melani; M Cohard

doi:10.1136/gut.49.1.42

Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

J F Colombel, P Rutgeerts, H Malchow, M Jacyna, O H Nielsen, J Rask-Madsen, S Van Deventer, A Ferguson, P Desreumaux, A Forbes, K Geboes, L Melani, M Cohard

Research output: Contribution to journal › Article › peer-review

233 Citations (Scopus)

Abstract

New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety and tolerance of recombinant human interleukin 10 (IL-10; Tenovil) in subjects operated on for Crohn's disease. We also assessed the effect of Tenovil in preventing endoscopic recurrence 12 weeks after surgery.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	Gut
Volume	49
Issue number	1
DOIs	https://doi.org/10.1136/gut.49.1.42
Publication status	Published - Jul 2001

Keywords

Adult
Chemotherapy, Adjuvant
Colonoscopy
Crohn Disease
Double-Blind Method
Electrophoresis, Agar Gel
Female
Hematocrit
Hemoglobins
Humans
Interleukin-1
Interleukin-10
Intestinal Mucosa
Male
Patient Compliance
Recurrence
Reverse Transcriptase Polymerase Chain Reaction
Statistics, Nonparametric
Treatment Outcome
Tumor Necrosis Factor-alpha

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/gut.49.1.42

Cite this

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title = "Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease",

abstract = "New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety and tolerance of recombinant human interleukin 10 (IL-10; Tenovil) in subjects operated on for Crohn's disease. We also assessed the effect of Tenovil in preventing endoscopic recurrence 12 weeks after surgery.",

keywords = "Adult, Chemotherapy, Adjuvant, Colonoscopy, Crohn Disease, Double-Blind Method, Electrophoresis, Agar Gel, Female, Hematocrit, Hemoglobins, Humans, Interleukin-1, Interleukin-10, Intestinal Mucosa, Male, Patient Compliance, Recurrence, Reverse Transcriptase Polymerase Chain Reaction, Statistics, Nonparametric, Treatment Outcome, Tumor Necrosis Factor-alpha",

author = "Colombel, {J F} and P Rutgeerts and H Malchow and M Jacyna and Nielsen, {O H} and J Rask-Madsen and {Van Deventer}, S and A Ferguson and P Desreumaux and A Forbes and K Geboes and L Melani and M Cohard",

year = "2001",

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T1 - Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

AU - Colombel, J F

AU - Rutgeerts, P

AU - Malchow, H

AU - Jacyna, M

AU - Nielsen, O H

AU - Rask-Madsen, J

AU - Van Deventer, S

AU - Ferguson, A

AU - Desreumaux, P

AU - Forbes, A

AU - Geboes, K

AU - Melani, L

AU - Cohard, M

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AB - New lesions of Crohn's disease occur early after ileal or ileocolonic resection and ileocolonic anastomosis. We performed a double blind controlled trial to evaluate the safety and tolerance of recombinant human interleukin 10 (IL-10; Tenovil) in subjects operated on for Crohn's disease. We also assessed the effect of Tenovil in preventing endoscopic recurrence 12 weeks after surgery.

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KW - Chemotherapy, Adjuvant

KW - Colonoscopy

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KW - Double-Blind Method

KW - Electrophoresis, Agar Gel

KW - Female

KW - Hematocrit

KW - Hemoglobins

KW - Humans

KW - Interleukin-1

KW - Interleukin-10

KW - Intestinal Mucosa

KW - Male

KW - Patient Compliance

KW - Recurrence

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Statistics, Nonparametric

KW - Treatment Outcome

KW - Tumor Necrosis Factor-alpha

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