Abstract
Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.
| Original language | English |
|---|---|
| Pages (from-to) | 109-116 |
| Number of pages | 8 |
| Journal | Cytokine & Growth Factor Reviews |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - Jun 1998 |
Keywords
- Amino Acid Sequence
- Animals
- Autoimmunity
- Diabetes Mellitus, Type 1/immunology
- Gene Expression
- Humans
- Interleukin-1/genetics
- Interleukin-18/genetics
- Interleukin-18 Receptor alpha Subunit
- Molecular Sequence Data
- Neoplasms, Experimental/immunology
- Osteoclasts/cytology
- Receptors, Interleukin/physiology
- Receptors, Interleukin-18
- T-Lymphocytes/immunology
