Interleukin-18: perspectives on the newest interleukin

M T Gillespie, N J Horwood

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)


Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCytokine & Growth Factor Reviews
Issue number2
Publication statusPublished - Jun 1998


  • Amino Acid Sequence
  • Animals
  • Autoimmunity
  • Diabetes Mellitus, Type 1/immunology
  • Gene Expression
  • Humans
  • Interleukin-1/genetics
  • Interleukin-18/genetics
  • Interleukin-18 Receptor alpha Subunit
  • Molecular Sequence Data
  • Neoplasms, Experimental/immunology
  • Osteoclasts/cytology
  • Receptors, Interleukin/physiology
  • Receptors, Interleukin-18
  • T-Lymphocytes/immunology

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