Internal anal sphincter atrophy in patients with systemic sclerosis

Nora M Thoua, Alexis Schizas, Alastair Forbes, Christopher P Denton, Anton V Emmanuel

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


SSc is a connective tissue, multisystem disorder of unknown aetiology. The gastrointestinal tract (GIT) is affected in up to 90% of patients. The exact pathophysiology of GIT involvement is not known, but it is related to both neurogenic and myogenic abnormalities as well as possible vascular and ischaemic changes. Thinning of the internal anal sphincter (IAS) has been demonstrated in SSc with faecal incontinence. We aimed to investigate anal sphincter structure in patients with SSc.
Original languageEnglish
Pages (from-to)1596-602
Number of pages7
Issue number9
Publication statusPublished - Sep 2011


  • Adult
  • Aged
  • Anal Canal
  • Case-Control Studies
  • Endosonography
  • Fecal Incontinence
  • Female
  • Humans
  • Intestinal Diseases
  • Male
  • Manometry
  • Middle Aged
  • Questionnaires
  • Scleroderma, Systemic

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