Internal anal sphincter atrophy in patients with systemic sclerosis

Nora M Thoua, Alexis Schizas, Alastair Forbes, Christopher P Denton, Anton V Emmanuel

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

SSc is a connective tissue, multisystem disorder of unknown aetiology. The gastrointestinal tract (GIT) is affected in up to 90% of patients. The exact pathophysiology of GIT involvement is not known, but it is related to both neurogenic and myogenic abnormalities as well as possible vascular and ischaemic changes. Thinning of the internal anal sphincter (IAS) has been demonstrated in SSc with faecal incontinence. We aimed to investigate anal sphincter structure in patients with SSc.
Original languageEnglish
Pages (from-to)1596-602
Number of pages7
JournalRheumatology
Volume50
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Adult
  • Aged
  • Anal Canal
  • Case-Control Studies
  • Endosonography
  • Fecal Incontinence
  • Female
  • Humans
  • Intestinal Diseases
  • Male
  • Manometry
  • Middle Aged
  • Questionnaires
  • Scleroderma, Systemic

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